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Anus and perianal area

Benign or non-neoplastic lesions


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Intramural tumors are rare; when found are often in young women
● Leiomyomas of muscularis mucosa more common; small and present as intraluminal polyps
● Leiomyomas externally attached to rectum occur almost always in women, ER+, PR+, CD117-, analogous to uterine leiomyomas

Gross description

● In small study, rectal tumors were 1.5-4 cm

Micro description

● Limited cellularity resembling esophageal leiomyoma or higher cellularity without mitotic activity

Positive stains

● Alpha smooth muscle actin, desmin

Negative stains

● CD117, CD34

End of Anus and perianal area > Benign or non-neoplastic lesions > Leiomyoma

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