Anus & perianal
Metastases to anus or perianal area

Topic Completed: 1 December 2014

Revised: 20 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Metastases [title] anus

Raul S. Gonzalez, M.D.
Page views in 2018: 108
Page views in 2019 to date: 154
Cite this page: Gonzalez RS. Metastases to anus or perianal area. website. Accessed October 16th, 2019.
Definition / general
  • Most common site of origin is rectum (ie, local metastasis to anus)
  • Distant metastasis to anus is extremely rare; examples of pulmonary, mammary, renal and ampullary carcinomas spreading to the anus have been reported
Clinical features
  • May present as an anal fissure or be discovered during examination of a hemorrhoidectomy specimen
  • Rarely can be first manifestation of the primary malignancy
Case reports
Microscopic (histologic) description
  • Likely resembles primary malignancy; histology and immunostaining can be helpful if clinical history is unknown or primary tumor is undiscovered
Microscopic (histologic) images

Images hosted on other servers:

Renal cell carcinoma metastatic to anus

Rectal adenocarcinoma metastatic to anus

Ampullary adenocarcinoma

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