Anus and perianal area
Metastases to anus or perianal area

Author: Raul Gonzalez, M.D. (see Authors page)

Revised: 11 October 2017, last major update December 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Metastases [title] anus

Cite this page: Gonzalez, R. Metastases to anus or perianal area. website. Accessed June 19th, 2018.
Definition / general
  • Most common site of origin is rectum (ie, local metastasis to anus)
  • Distant metastasis to anus is extremely rare; examples of pulmonary, mammary, renal and ampullary carcinomas spreading to the anus have been reported
Clinical features
  • May present as an anal fissure or be discovered during examination of a hemorrhoidectomy specimen
  • Rarely can be first manifestation of the primary malignancy
Case reports
Microscopic (histologic) description
  • Likely resembles primary malignancy; histology and immunostaining can be helpful if clinical history is unknown or primary tumor is undiscovered
Microscopic (histologic) images

Images hosted on other servers:

Renal cell carcinoma metastatic to anus

Rectal adenocarcinoma metastatic to anus

Ampullary adenocarcinoma