Anus and perianal area
Carcinoma
Paget disease

Author: Raul Gonzalez, M.D. (see Authors page)

Revised: 17 October 2017, last major update November 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Paget disease anus "loattrfree full text"[sb]

Cite this page: Gonzalez, R. Paget disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/anuspagets.html. Accessed October 23rd, 2017.
Definition / general
  • Intraepithelial tumor of apocrine or possibly eccrine gland origin
Epidemiology
  • Primary extramammary anal Paget disease is rare
  • Men and women are equally affected
  • Most often occurs in the fifth to seventh decade
  • Typically indolent but often recurs
  • About 15% of patients with anal Paget have secondary disease (associated with an underlying malignancy)
Sites
  • Arises anywhere between the dentate line and the perianal skin
Treatment
Clinical images

Images hosted on other servers:

Extensive perianal Paget disease, perineum

Early response

Notable telangiectasia and fibrosis

Gross description
  • Erythematous, ulcerated or eczematous plaques or patches
Microscopic (histologic) description
  • Large, pale staining to clear intraepidermal neoplastic cells containing abundant mucin, arranged singly or occasionally in nests or gland-like formations
  • Cells are more numerous basally
  • Microscopic disease may extend beyond grossly visible changes
  • Associated changes include squamous hyperplasia, fibroepithelioma-like hyperplasia and papillomatous hyperplasia (Am J Surg Pathol 2000;24:543)
Microscopic (histologic) images

Images hosted on other servers:

Anal Paget disease (lower image)

     

Secondary anal Paget disease
(first image) with associated
adenocarcinoma

Positive stains
Negative stains
Differential diagnosis