Anus and perianal area
Sarcomatoid carcinoma

Author: Raul Gonzalez, M.D. (see Authors page)

Revised: 17 October 2017, last major update November 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sarcomatoid carcinoma [title] "loattrfree full text"[sb]

Cite this page: Gonzalez, R. Sarcomatoid carcinoma. website. Accessed June 19th, 2018.
Definition / general
  • Rare epithelial malignancy of the anus with areas morphologically resembling sarcoma
  • Also called spindle cell carcinoma or pseudosarcomatous carcinoma; "carcinosarcoma" has been used interchangeably but suggests true sarcomatous differentiation (Pathology 2006;38:264)
  • Extremely rare in the anus, as in the colon
Case reports
  • Surgery
Microscopic (histologic) description
  • Carcinoma with a well differentiated component (such as squamous cell carcinoma or adenocarcinoma) and a poorly differentiated component that resembles sarcoma (ie, spindle cell morphology) but demonstrates epithelial characteristics by immunohistochemistry or electron microscopy
Microscopic (histologic) images

Images hosted on other servers:

Anal biopsy

Positive stains
Differential diagnosis
  • Carcinosarcoma: biphasic tumor with an epithelial component and a truly mesenchymal component