Anus & perianal
Sarcomatoid carcinoma

Topic Completed: 1 November 2014

Minor changes: 19 August 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: Sarcomatoid carcinoma [title] "loattrfree full text"[sb]

Raul S. Gonzalez, M.D.
Page views in 2019: 392
Page views in 2020 to date: 189
Cite this page: Gonzalez RS. Sarcomatoid carcinoma. website. Accessed June 3rd, 2020.
Definition / general
  • Rare epithelial malignancy of the anus with areas morphologically resembling sarcoma
  • Also called spindle cell carcinoma or pseudosarcomatous carcinoma; "carcinosarcoma" has been used interchangeably but suggests true sarcomatous differentiation (Pathology 2006;38:264)
  • Extremely rare in the anus, as in the colon
Case reports
  • Surgery
Microscopic (histologic) description
  • Carcinoma with a well differentiated component (such as squamous cell carcinoma or adenocarcinoma) and a poorly differentiated component that resembles sarcoma (ie, spindle cell morphology) but demonstrates epithelial characteristics by immunohistochemistry or electron microscopy
Microscopic (histologic) images

Images hosted on other servers:

Anal biopsy

Positive stains
Differential diagnosis
  • Carcinosarcoma: biphasic tumor with an epithelial component and a truly mesenchymal component
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