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Anus and perianal area


Small cell (neuroendocrine) carcinoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Rare, very aggressive, 5 year survival only 10%
● Associated with HPV
● Usually presents with disseminated disease

Micro description

● Undifferentiated tumor composed of solid nests of small cells with minimal cytoplasm, hyperchromatic nuclei with molding, central necrosis
● Resembles pulmonary tumor

Positive stains

● Chromogranin (usually), synaptophysin, neuron specific enolase, Leu7/CD57

Differential diagnosis

Basaloid squamous cell carcinoma

End of Anus and perianal area > Carcinoma > Small cell (neuroendocrine) carcinoma

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