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Anus and perianal area

Carcinoma

Small cell (neuroendocrine) carcinoma


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Rare, very aggressive, 5 year survival only 10%
● Associated with HPV
● Usually presents with disseminated disease

Micro description
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● Undifferentiated tumor composed of solid nests of small cells with minimal cytoplasm, hyperchromatic nuclei with molding, central necrosis
● Resembles pulmonary tumor

Positive stains
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● Chromogranin (usually), synaptophysin, neuron specific enolase, Leu7/CD57

Differential diagnosis
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Basaloid squamous cell carcinoma

End of Anus and perianal area > Carcinoma > Small cell (neuroendocrine) carcinoma


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