Anus and perianal area
Carcinoma
Small cell (neuroendocrine) carcinoma

Author: Raul Gonzalez, M.D. (see Authors page)

Revised: 17 October 2017, last major update December 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: small cell carcinoma anus "loattrfree full text"[sb]

Cite this page: Gonzalez, R. Small cell (neuroendocrine) carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/anussmallcell.html. Accessed October 23rd, 2017.
Definition / general
  • Poorly differentiated neuroendocrine carcinoma arising in the anus
  • Rare and very aggressive, with early metastatic spread; 5 year survival approximately 10%
Epidemiology
Pathophysiology
Case reports
Treatment
  • Chemotherapy and radiation
Clinical images

Images hosted on other servers:

MRI

PET scan

Metastatic disease

Microscopic (histologic) description
  • Poorly differentiated neuroendocrine tumor composed of solid nests of small cells with minimal cytoplasm, hyperchromatic nuclei with molding, central necrosis and high mitotic activity
  • Resembles pulmonary counterpart
  • May have overlying squamous cell carcinoma in situ (Pathol Int 2012;62:356)
Microscopic (histologic) images

Images hosted on other servers:

Small cell carcinoma

AE1 / 3, p63

High grade

Positive stains
Negative stains
  • CDX2 (positive in rectal small cell carcinomas)
Differential diagnosis