Anus and perianal area
Verrucous carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 17 October 2017, last major update January 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Verrucous carcinoma anus

Cite this page: Gonzalez, R. Verrucous carcinoma. website. Accessed May 21st, 2018.
Definition / general
  • Uncommon lower grade variant of squamous cell carcinoma
  • Considered intermediate between condyloma acuminatum and squamous cell carcinoma
  • Giant condyloma acuminatum / Buschke-Löwenstein tumor: may represent the same entity or spectrum of disease (Histopathology 1985;9:1155)
  • Large condyloma acuminatum term has been proposed for tumors 2 - 10 cm, with "giant" referring to those > 10 cm (Mod Pathol 2008;21:112A)
  • More common in men
Clinical features
  • Large anal tumor (often > 10 cm) that may be accompanied by abscess or fistula
  • Often will recur but does not metastasize; mortality is approximately 20% (Dis Colon Rectum 1994;37:950)
Case reports
Clinical images

Images hosted on other servers:

Verrucous carcinoma

Gross description
  • Polypoid; resembles a condyloma but is larger
Microscopic (histologic) description
  • Very well differentiated squamous malignancy with minimal atypia and pushing borders
  • Locally destructive, without obvious invasive features, lymphovascular invasion etc.
  • Can exhibit surface maturation and extensive keratinization
  • May transform into conventional squamous cell carcinoma; rate of such transformation may be dependent on tumor size
  • Similar to verrucous carcinoma at other sites
Differential diagnosis