Benign tumors
Granular cell tumor

Reviewer: Jaleh Mansouri, M.D. (see Authors page)

Revised: 23 February 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Granular cell tumor appendix
Cite this page: Granular cell tumor. website. Accessed July 16th, 2018.
Definition / general
  • Similar to granular cell tumors at other sites, but uncommon in appendix
  • Case reports
  • 62 year old woman with submucosal rectosigmoid mass (J Gastrointestin Liver Dis 2009;18:475)
  • Microscopic (histologic) description
  • Polygonal cells with granular cytoplasm and bland nuclei
  • Positive stains
  • S100, PAS
  • Differential diagnosis
  • Granular cell transformation of appendiceal smooth muscle: S100-