Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Appendix

Other tumors

L-cell carcinoid tumor (tubular carcinoid)


Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 20 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

See also carcinoid and goblet cell carcinoid

General
=========================================================================

● Carcinoid tumor, much less common than classic tumors with insular pattern (EC-cell tumors); cell of origin is usually the L-cell, which produces enteroglucagons and peptide YY (Arch Pathol Lab Med 2010;134:1612)
● Minimal metastatic potential

Gross description
=========================================================================

● Small nodules at tip, often not identified grossly

Micro description
=========================================================================

● Columns, ribbons, acini or small tubules of small round cells with pale eosinophilic cytoplasm and round/oval nuclei with small nucleoli
● No/rare mitotic activity
● No insular masses
● May have dominant glandular, infiltrative pattern resembling metastatic carcinoma

Micro images
=========================================================================



Left: typical carcinoid (insular pattern); right: L-cell carcinoid (tubular carcinoid)

Positive stains
=========================================================================

● Chromogranin B, synaptophysin, CEA, glucagon, peptide YY, pancreatic polypeptide

Negative stains
=========================================================================

● Mucin, chromogranin A (usually)

Differential diagnosis
=========================================================================

● Well-differentiated metastatic adenocarcinoma: CK7/CK20 staining is nonspecific and represents potential diagnostic pitfall (J Clin Pathol 2012;65:666)

End of Appendix > Other tumors > L-cell carcinoid tumor (tubular carcinoid)


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).