Appendix
Appendicitis
Crohn's disease

Reviewer: Jaleh Mansouri, M.D. (see Authors page)

Revised: 15 February 2016, last major update August 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Crohn's disease appendix
Definition / General
  • Involves appendix in 25% of patients, may simulate acute appendicitis
  • Rare to initially or only involve the appendix
  • If limited to appendix, consider as granulomatous appendicitis; 90% of these patients do NOT develop disease elsewhere in GI tract

  • Diagnostic criteria:
    • Granulomas, transmural lymphoid aggregates, fissure-type ulcers
Differential Diagnosis
  • Yersinia, Mycobacteria or Actinomyces infections