Appendix
General
Endometriosis

Reviewer: Jaleh Mansouri, M.D., (see Authors page)

Revised: 26 January 2016, last major update August 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Endometriosis appendix
Definition / General
  • Women of reproductive age or post-menopausal women with hormone replacement therapy
  • Appendix is common site of intestinal involvement
  • Associated with endometrial hyperplasia, MMMT, endometrial carcinoma
Case Reports
Gross Description
  • Serosal nodule or blood-filled ("chocolate") cyst
  • Rarely causes appendiceal rupture
Micro Description
  • Endometrial glands, endometrial stroma, hemosiderin
  • May have muscular hypertrophy, overlying mucosa may be ulcerated
  • No dysplasia
Micro Images

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Endometriosis of appendix

Positive Stains
  • CD10 (stroma)
Differential Diagnosis
  • Invasive well differentiated adenocarcinoma