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Appendix

Endometriosis

Reviewer: Jaleh Mansouri, M.D., (see Reviewers page)
Revised: 15 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Women of reproductive age or post-menopausal women with hormone replacement therapy
● Appendix is common site of intestinal involvement
● Associated with endometrial hyperplasia, MMMT, endometrial carcinoma

Case reports
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● Mucocele of appendix secondary to obstruction by endometriosis (Hum Pathol 1977;8:585)

Gross description
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● Serosal nodule or blood-filled (“chocolate”) cyst
● Rarely causes appendiceal rupture

Gross images
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Serosal hemorrhagic nodule

Micro description
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● Endometrial glands, endometrial stroma, hemosiderin
● May have muscular hypertrophy, overlying mucosa may be ulcerated
● No dysplasia

Micro images
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Endometriosis of appendix

Positive stains
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● CD10 (stroma)

Differential diagnosis
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● Invasive well differentiated adenocarcinoma

End of Appendix > Endometriosis

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