Benign tumors
Hyperplastic polyp / mucinous hyperplasia

Reviewer: Jaleh Mansouri, M.D. (see Authors page)

Revised: 23 February 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Hyperplastic polyp appendix
Clinical Features
  • Resembles colonic hyperplastic polyp
  • More common in women, which may reflect higher incidence of incidental appendectomy in women
  • Usually age 40+ years
  • Associated with adenocarcinoma of right colon, although not precancerous per se
  • Gross Description
  • Usually sessile or flat
  • May appear as diffuse lesion without well-defined borders
  • Micro Description
  • Resembles colonic hyperplastic polyp: columnar and goblet cell proliferation with elongated and dilated tubules
  • Luminal outlines are serrated
  • Minimal hyperchromasia and no stratification
  • Differential Diagnosis
  • Villous adenoma (dysplastic nuclei), serrated polyp with abnormal proliferation/sessile serrated polyp/sessile serrated adenoma (Am J Clin Pathol 2010;133:623)