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Granulomatous appendicitis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 20 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Identified in 0.1% to 2.0% of appendectomies
● Clinically resembles acute appendicitis
● Does not recur after appendectomy; only 5-10% develop Crohn’s disease in GI tract (Hum Pathol 1986;17:1116)
● Causes: usually idiopathic; also Yersinia, foreign body reactions, interval appendicitis, Mycobacterium tuberculosis, pinworm (Enterobius vermicularis), sarcoidosis

Case report

● 26 year old woman (Surg Today 2007;37:690)

Micro description

● Resembles Crohn’s disease with focal cryptitis, crypt abscesses, mucosal erosion and ulceration, fissures, transmural lymphoid aggregates, mural fibrosis
● More granulomas than Crohn’s (20 vs. 0.3 per tissue section, Hum Pathol 1993;24:595)
● Usually no fistulas

End of Appendix > Appendicitis > Granulomatous appendicitis

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