Granulomatous appendicitis

Reviewer: Jaleh Mansouri, M.D. (see Authors page)

Revised: 16 February 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Granulomatous appendicitis
Cite this page: Granulomatous appendicitis. website. Accessed May 21st, 2018.
Definition / general
  • Identified in 0.1% to 2.0% of appendectomies
  • Clinically resembles acute appendicitis
  • Does not recur after appendectomy; only 5-10% develop Crohn’s disease in GI tract (Hum Pathol 1986;17:1116)
  • Causes: usually idiopathic; also Yersinia, foreign body reactions, interval appendicitis, Mycobacterium tuberculosis, pinworm (Enterobius vermicularis), sarcoidosis
Case reports
Microscopic (histologic) description
  • Resembles Crohn’s disease with focal cryptitis, crypt abscesses, mucosal erosion and ulceration, fissures, transmural lymphoid aggregates, mural fibrosis
  • More granulomas than Crohn’s (20 vs. 0.3 per tissue section, Hum Pathol 1993;24:595)
  • Usually no fistulas