Sessile serrated polyp
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 21 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Also known as sessile serrated adenoma or serrated polyp with abnormal proliferation
● Recently described entity with characteristic morphologic and genetic abnormalities (Am J Clin Pathol 2010;133:623); may include prior cases of focal mucosal hyperplasia
● Shares some overlapping features with serrated lesions of colon with risk of malignant transformation
● Exhibits mutations of BRAF and loss of mismatch repair enzymes
● Closely resembles hyperplastic polyp but displays irregular crypt branching (horizontal axis) and dilation and serration of crypt bases, mature mucinous cells at base of crypts
Appendiceal serrated lesions
● Hyperplastic polyp: no irregular crypt branching
● Adenoma (conventional): dysplasia present but no irregular crypt branching
End of Appendix > Benign tumors > Sessile serrated polyp
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