Home
Chapter Home
Jobs
Conferences
Fellowships
Books
Advertisement
Appendix
Benign tumors
Sessile serrated polyp
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 21 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
General
=========================================================================
● Also known as sessile serrated adenoma or serrated polyp with abnormal proliferation
● Recently described entity with characteristic morphologic and genetic abnormalities (Am J Clin Pathol 2010;133:623); may include prior cases of focal mucosal hyperplasia
● Shares some overlapping features with serrated lesions of colon with risk of malignant transformation
● Exhibits mutations of BRAF and loss of mismatch repair enzymes
Micro description
=========================================================================
● Closely resembles hyperplastic polyp but displays irregular crypt branching (horizontal axis) and dilation and serration of crypt bases, mature mucinous cells at base of crypts
Micro images
=========================================================================
Appendiceal serrated lesions
Differential diagnosis
=========================================================================
● Hyperplastic polyp: no irregular crypt branching
● Adenoma (conventional): dysplasia present but no irregular crypt branching
End of Appendix > Benign tumors > Sessile serrated polyp
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other
contact information).