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Bladder
Other tumors
Gastrointestinal stromal tumor (GIST)
Author: Nat Pernick, M.D. (see Authors page)
Revised: 26 December 2009, last major update - December 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
See also Stomach-GIST
Definition
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● Very rare tumor of CD117+ spindled or epithelioid cells, similar to counterpart in GI tract
● Reported cases are typically attached to external wall of bladder
Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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● 34 year old man with tumor attached to external bladder (Pathologica 2008;100:173)
● 52 year old woman with tumor attached to external bladder (Archives 2000;124:894)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Sheets of spindle cells with dense collagenous background, mitoses are usually rare
Micro images
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Cytology description
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Cytology images
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Positive stains
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● CD117 (c-kit), CD34
Negative stains
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● S100, desmin
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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● c-kit mutations in exon 11
Molecular / cytogenetics images
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Differential Diagnosis
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● Leiomyoma: smooth muscle phenotype with slender spindle cells containing eosinophilic cytoplasm and cigar shaped nuclei; desmin+, alpha smooth muscle actin+, CD117-, CD34-, no c-kit mutation
● Schwannoma: biphasic spindled tumor; nuclei have tapering ends; S100+, CD117-, CD34-, no c-kit mutation
Additional references
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End of Bladder > Other tumors > Gastrointestinal stromal tumor (GIST)
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