Bladder
Other tumors
Gastrointestinal stromal tumor (GIST)

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 2 August 2016, last major update December 2014

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PubMed Search: Bladder GIST

See also: Stomach-GIST
Cite this page: Gastrointestinal stromal tumor (GIST). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladderGIST.html. Accessed December 9th, 2016.
Definition / General
  • Very rare mesenchymal tumor of CD117+ spindled or epithelioid cells, similar to counterpart in GI tract
  • Reported cases are typically attached to external wall of bladder
Etiology
  • Arises from interstitial cells of Cajal
Case Reports
Treatment
  • Surgery, possibly kinase inhibitors such as imatinib mesylate (Gleevec)
Micro Description
  • Sheets of spindled or epithelioid cells with dense collagenous background; mitoses are usually rare
Micro Images

Images hosted on other servers:
Missing Image

Various images

Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • c-kit mutations in exons 9 and 11
  • PDGFRA mutation
Differential Diagnosis
  • Leiomyoma: smooth muscle phenotype with slender spindle cells containing eosinophilic cytoplasm and cigar shaped nuclei; desmin+, alpha smooth muscle actin+, CD117-, CD34-, no c-kit mutation
  • Schwannoma: biphasic spindled tumor; nuclei have tapering ends; S100+, CD117-, CD34-, no c-kit mutation
  • Inflammatory myofibroblast tumor: tissue culture growth pattern, ALK+, CD117-