Bladder & ureters
Other tumors
Gastrointestinal stromal tumor (GIST)

Topic Completed: 1 December 2014

Revised: 27 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Bladder GIST

See also: Stomach-GIST

Turki Al-Hussain, M.D.
Page views in 2019: 942
Page views in 2020 to date: 257
Cite this page: Al-Hussain T. Gastrointestinal stromal tumor (GIST). website. Accessed April 9th, 2020.
Definition / general
  • Very rare mesenchymal tumor of CD117+ spindled or epithelioid cells, similar to counterpart in GI tract
  • Reported cases are typically attached to external wall of bladder
  • Arises from interstitial cells of Cajal
Case reports
  • Surgery, possibly kinase inhibitors such as imatinib mesylate (Gleevec)
Microscopic (histologic) description
  • Sheets of spindled or epithelioid cells with dense collagenous background; mitoses are usually rare
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • c-kit mutations in exons 9 and 11
  • PDGFRA mutation
Differential diagnosis
  • Leiomyoma: smooth muscle phenotype with slender spindle cells containing eosinophilic cytoplasm and cigar shaped nuclei; desmin+, alpha smooth muscle actin+, CD117-, CD34-, no c-kit mutation
  • Schwannoma: biphasic spindled tumor; nuclei have tapering ends; S100+, CD117-, CD34-, no c-kit mutation
  • Inflammatory myofibroblast tumor: tissue culture growth pattern, ALK+, CD117-
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