Bladder & ureters
Other tumors
Gastrointestinal stromal tumor (GIST)


Topic Completed: 1 December 2014

Revised: 27 June 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Bladder GIST

See also: Stomach-GIST

Turki Al-Hussain, M.D.
Page views in 2018: 883
Page views in 2019 to date: 555
Cite this page: Al-Hussain T. Gastrointestinal stromal tumor (GIST). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladderGIST.html. Accessed July 20th, 2019.
Definition / general
  • Very rare mesenchymal tumor of CD117+ spindled or epithelioid cells, similar to counterpart in GI tract
  • Reported cases are typically attached to external wall of bladder
Etiology
  • Arises from interstitial cells of Cajal
Case reports
Treatment
  • Surgery, possibly kinase inhibitors such as imatinib mesylate (Gleevec)
Microscopic (histologic) description
  • Sheets of spindled or epithelioid cells with dense collagenous background; mitoses are usually rare
Microscopic (histologic) images

Images hosted on other servers:
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Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • c-kit mutations in exons 9 and 11
  • PDGFRA mutation
Differential diagnosis
  • Leiomyoma: smooth muscle phenotype with slender spindle cells containing eosinophilic cytoplasm and cigar shaped nuclei; desmin+, alpha smooth muscle actin+, CD117-, CD34-, no c-kit mutation
  • Schwannoma: biphasic spindled tumor; nuclei have tapering ends; S100+, CD117-, CD34-, no c-kit mutation
  • Inflammatory myofibroblast tumor: tissue culture growth pattern, ALK+, CD117-
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