Other tumors
Gastrointestinal stromal tumor (GIST)

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 2 August 2016, last major update December 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Bladder GIST

See also: Stomach-GIST
Cite this page: Gastrointestinal stromal tumor (GIST). website. Accessed March 28th, 2017.
Definition / General
  • Very rare mesenchymal tumor of CD117+ spindled or epithelioid cells, similar to counterpart in GI tract
  • Reported cases are typically attached to external wall of bladder
  • Arises from interstitial cells of Cajal
Case Reports
  • Surgery, possibly kinase inhibitors such as imatinib mesylate (Gleevec)
Micro Description
  • Sheets of spindled or epithelioid cells with dense collagenous background; mitoses are usually rare
Micro Images

Images hosted on other servers:
Missing Image

Various images

Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • c-kit mutations in exons 9 and 11
  • PDGFRA mutation
Differential Diagnosis
  • Leiomyoma: smooth muscle phenotype with slender spindle cells containing eosinophilic cytoplasm and cigar shaped nuclei; desmin+, alpha smooth muscle actin+, CD117-, CD34-, no c-kit mutation
  • Schwannoma: biphasic spindled tumor; nuclei have tapering ends; S100+, CD117-, CD34-, no c-kit mutation
  • Inflammatory myofibroblast tumor: tissue culture growth pattern, ALK+, CD117-