Other tumors

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 1 August 2016, last major update December 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Bladder angiosarcoma
Cite this page: Angiosarcoma. website. Accessed October 27th, 2016.
Definition / General
  • Rare vascular tumor with anastomosing vascular channels
  • Endothelial cells usually exhibit marked cytologic atypia
  • Mean age 64 years, 89% occur in males
  • Due to radiation therapy for pelvic malignancy in 1/3; also exposure to arsenic, thorium dioxide, polyvinyl chloride or chemotherapeutic agents
  • It has been reported to arise in bladder with preexisting hemangioma
Clinical Features
Case Reports
  • Wide radical resection, possibly radiotherapy/chemotherapy
Gross Description
  • Hemorrhagic, raised mass (mean 7 cm) of trigone or dome
Micro Description
  • Anastomosing vascular channels lined by plump hyperchromatic cells
  • Also solid growth and epithelioid cytology
  • Typically invades the muscularis propria (Am J Surg Pathol 2008;32:1213)
Micro Images

Images hosted on other servers:
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Anastomosing vascular channels

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Endothelial cells

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Various images

Positive Stains
Differential Diagnosis
  • Hemangioma: typically 1 cm or less, 80% are cavernous, no atypia, no anastomosing or solid areas
  • Kaposi‚Äôs sarcoma: associated with HIV and HHV8; extravasated red blood cells present; usually less atypia than angiosarcoma
  • Sarcomatoid urothelial carcinoma: undifferentiated spindle cells; associated urothelial carcinoma; vascular markers are negative