Bladder
Other tumors
Angiosarcoma



Topic Completed: 1 December 2014

Revised: 24 December 2018

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Bladder angiosarcoma
Page views in 2018: 274
Page views in 2019 to date: 128
Cite this page: Al-Hussain T Angiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladderangiosarcoma.html. Accessed May 22nd, 2019.
Definition / general
  • Rare vascular tumor with anastomosing vascular channels
  • Endothelial cells usually exhibit marked cytologic atypia
Epidemiology
  • Mean age 64 years, 89% occur in males
Etiology
  • Due to radiation therapy for pelvic malignancy in 1/3; also exposure to arsenic, thorium dioxide, polyvinyl chloride or chemotherapeutic agents
  • It has been reported to arise in bladder with preexisting hemangioma
Clinical features
Case reports
Treatment
  • Wide radical resection, possibly radiotherapy/chemotherapy
Gross description
  • Hemorrhagic, raised mass (mean 7 cm) of trigone or dome
Microscopic (histologic) description
  • Anastomosing vascular channels lined by plump hyperchromatic cells
  • Also solid growth and epithelioid cytology
  • Typically invades the muscularis propria (Am J Surg Pathol 2008;32:1213)
Microscopic (histologic) images

Images hosted on other servers:
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Anastomosing vascular channels

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Endothelial cells

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Various images

Positive stains
Differential diagnosis
  • Hemangioma: typically 1 cm or less, 80% are cavernous, no atypia, no anastomosing or solid areas
  • Kaposi‚Äôs sarcoma: associated with HIV and HHV8; extravasated red blood cells present; usually less atypia than angiosarcoma
  • Sarcomatoid urothelial carcinoma: undifferentiated spindle cells; associated urothelial carcinoma; vascular markers are negative
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