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Bladder
Cystitis
Chronic cystitis
Author: Nat Pernick, M.D. (see Authors page)
Revised: 25 December 2009, last major update - December 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Chronic inflammatory cell infiltrate of lamina propria, due to recurrent or prolonged urinary tract infections
Terminology
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● Includes follicular cystitis
Epidemiology
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● More common in women, most likely because urethra is shorter
Sites
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Etiology
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● Typically due to repeated bouts of urinary tract infections
Clinical features
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Prognostic factors
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Case reports
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Treatment
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Clinical images
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Gross description (Macroscopy)
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● Heaping of mucosa
● Red, friable, ulcerated mucosa
Gross images
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Micro description (Histopathology)
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● Chronic inflammatory cell infiltrate
● Fibrous thickening of muscularis propria
● Often reactive epithelial atypia
● Note: florid chronic cystitis may mask urothelial carcinoma
Micro images
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With keratinizing squamous metaplasia, link
Cytology description
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● Nuclei are enlarged with prominent nucleoli
● Variable cytoplasmic vacuoles
Cytology images
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Reactive urothelial cells due to chronic cystitis #1; #2; #3; #4
Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● MALT lymphoma: forms solitary or multiple masses; monoclonal
Additional references
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End of Bladder > Cystitis > Chronic cystitis
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