Bladder & ureters
Nonurothelial benign tumors
Condyloma acuminatum

Topic Completed: 1 June 2011

Revised: 30 October 2019

Copyright: 2003-2019,, Inc.

PubMed Search: condyloma acuminatum[title]

Nat Pernick, M.D.
Page views in 2018: 595
Page views in 2019 to date: 678
Cite this page: Pernick N. Condyloma acuminatum. website. Accessed December 11th, 2019.
Definition / general
  • HPV related lesion similar to counterparts at other sites
  • Caused by HPV, almost always subtypes 6 and 11 and not 16 or 18
Clinical features
  • Rare to only involve the bladder, usually occurs by direct extension from genital lesions
  • Also associated with long-standing cystotomy, indwelling catheters, fistulas and immunosuppression
  • Usually not associated with squamous cell carcinoma of bladder (Am J Surg Pathol 2007;31:1777, Am J Surg Pathol 2006;30:883)
Case reports
  • Excision (surgical, chemical, laser, other); may recur, but doesn’t progress to carcinoma
Gross description
  • Smooth, pink-tan, papillary
Gross images

Images hosted on other servers:

Extensive bladder involvement

Microscopic (histologic) description
  • Resembles condylomas at other sites with papillary fronds lined by hyperplastic and metaplastic squamous epithelium with koilocytosis (perinuclear halos), wrinkled nuclei and binucleated cells
  • Variable atypia, but no anaplasia
Microscopic (histologic) images

Images hosted on other servers:


Positive stains
Differential diagnosis
Back to top