Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Bladder

Bladder tumors - benign

Condyloma accuminatum

Reviewers: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 27 June 2011, last major update June 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
=========================================================================

● HPV related lesion similar to counterparts at other sites

Etiology
=========================================================================

● Caused by HPV, almost always subtypes 6 and 11 and not 16 or 18

Clinical features
=========================================================================

● Rare to only involve the bladder, usually occurs by direct extension from genital lesions
● Also associated with long-standing cystotomy, indwelling catheters, fistulas and immunosuppression
● Usually not associated with squamous cell carcinoma of bladder (Am J Surg Pathol 2007;31:1777, Am J Surg Pathol 2006;30:883)

Case reports
=========================================================================

● Due to HPV 16/18 (Int J STD AIDS 2004;15:836, Am J Surg Pathol 1988;12:205)
● Progressing to poorly differentiated spindle cell carcinoma (Scand J Urol Nephrol 2003;37:512)
● 62 year old man with subsequent warty carcinoma (Int J Surg Pathol 2000;8:253)

Treatment
=========================================================================

● Excision (surgical, chemical, laser, other); may recur, but doesn’t progress to carcinoma

Gross description
=========================================================================

● Smooth, pink-tan, papillary

Gross images
=========================================================================

Extensive bladder involvement

Micro description
=========================================================================

● Resembles condylomas at other sites with papillary fronds lined by hyperplastic and metaplastic squamous epithelium with koilocytosis (perinuclear halos), wrinkled nuclei and binucleated cells
● Variable atypia, but no anaplasia

Micro images
=========================================================================

       
Condyloma

Positive stains
=========================================================================

● HPV 6, 11; p53

Differential diagnosis
=========================================================================

● Squamous papilloma: no koilocytosis, HPV negative; rare, usually affects elderly women, p53 negative (Cancer 2000;88:1679)
● Verrucous carcinoma: invasive margins, anaplasia, HPV negative

End of Bladder > Bladder tumors - benign > Condyloma accuminatum

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).