Nonurothelial benign tumors
Condyloma acuminatum

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 June 2016, last major update June 2011

Copyright: (c) 2003-2016,, Inc.

PubMed Search: condyloma acuminatum[title]
Cite this page: Condyloma acuminatum. website. Accessed December 11th, 2018.
Definition / general
  • HPV related lesion similar to counterparts at other sites
  • Caused by HPV, almost always subtypes 6 and 11 and not 16 or 18
Clinical features
  • Rare to only involve the bladder, usually occurs by direct extension from genital lesions
  • Also associated with long-standing cystotomy, indwelling catheters, fistulas and immunosuppression
  • Usually not associated with squamous cell carcinoma of bladder (Am J Surg Pathol 2007;31:1777, Am J Surg Pathol 2006;30:883)
Case reports
  • Excision (surgical, chemical, laser, other); may recur, but doesn’t progress to carcinoma
Gross description
  • Smooth, pink-tan, papillary
Gross images

Images hosted on other servers:

Extensive bladder involvement

Microscopic (histologic) description
  • Resembles condylomas at other sites with papillary fronds lined by hyperplastic and metaplastic squamous epithelium with koilocytosis (perinuclear halos), wrinkled nuclei and binucleated cells
  • Variable atypia, but no anaplasia
Microscopic (histologic) images

Images hosted on other servers:


Positive stains
Differential diagnosis