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Bladder
Acquired non-neoplastic anomalies
Author: Nat Pernick, M.D. (see Authors page)
Editor: name, affiliation
Revised: 11 February 2010, last major update - February 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Involvement of lamina propria and muscularis propria by tubules and cysts with tubal type epithelium (ciliated cells, intercalated cells, peg cells)
Terminology
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● Called mullerianosis if two of three (endocervicosis, endometriosis or endosalpingiosis) are present (Mod Path 1996;9:73)
Epidemiology
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Sites
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Etiology
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Clinical features
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● Associated with endocervicosis (glands lined by columnar mucinous cells) and endometriosis
Prognostic factors
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Case reports
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● 54 year old woman with pure endosalpingiosis, possibly implanted after surgery (Int J Surg Pathol 2009 Mar 11 [Epub ahead of print])
Treatment
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● Excision; may recur (Urology 2004;64:1031)
Clinical images
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Gross description (Macroscopy)
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● May form mass on posterior wall of bladder
Gross images
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Micro description (Histopathology)
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● Involvement of lamina propria and muscularis propria by tubules and cysts of mullerian-type epithelium
● May replace urothelium and form polypoid projections into bladder lumen
● Tubules and cysts are round/oval, may have prominent branching
● Glands are lined by tubal type epithelium (ciliated cells, intercalated cells, peg cells)
● No atypia, no mitotic figures, no necrosis
Micro images
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Uterine serosal lesion
Ovary: glands lined by ciliated epithelium lie in fibrous stroma; ciliated, secretory and intercalated cells line the cystic space
Site unknown: glands lined by tubal type epithelium #1; #2; site unknown
Omentum: CD34 and calretinin
Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Adenocarcinoma: marked atypia, invasive borders, usually not ciliated and lacks 3 types of tubal cells
Additional references
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End of Bladder > Acquired non-neoplastic anomalies > Endosalpingiosis
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