Other tumors
Germ cell tumor

Author: Gillian Levy, M.D. (see Authors page)

Revised: 2 August 2016, last major update December 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Bladder germ cell tumor [title]
Cite this page: Germ cell tumor. website. Accessed October 23rd, 2016.
Definition / General
  • Includes choriocarcinoma, dermoid cyst, seminoma, teratoma, yolk sac tumors
  • Dermoid cyst: typically females 30-49 years of age
Clinical Features
  • Dermoid cysts can contain hair and calcified material
  • Ovarian dermoid cysts may perforate into the bladder and must be excluded
Case Reports
  • Excision, radiation for seminomas
Gross Description
  • Yolk sac: yellow, soft
  • Seminoma: gray-tan mass
Micro Description
  • Choriocarcinoma: syncytotrophoblasts capping sheets of cytotrophoblasts (sheets or aggregates of single irregularly shaped nuclei)
  • Seminoma: sheets or lobules of seminoma cells divided by fibrous trabeculae with aggregates of lymphocytes
  • Yolk sac tumor: multiple patterns (microcystic, macrocystic, papillary and solid)
Micro Images

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Missing Image

Urachal yolk sac tumor

Cytology Description
  • Seminoma: loosely cohesive cell clusters of highly atypical large cells and occasional large, single cells with macronucleoli; background of mainly lymphocytes and histiocytes (Diagn Cytopathol 2008;36:734)
Positive Stains
Molecular / Cytogenetics Description
  • Isochromosome 12 present in germ cell tumors
Differential Diagnosis
Additional References