Home Chapter Home Jobs Conferences Fellowships Books
Advertisement
Bladder
Other Carcinomas
Hepatoid adenocarcinoma
Author: Nat Pernick, M.D. (see Authors page)
Revised: 23 December 2009, last major update - December 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
=========================================================================
● Very rare
Terminology
=========================================================================
●
Epidemiology
=========================================================================
●
Sites
=========================================================================
●
Etiology
=========================================================================
●
Clinical features
=========================================================================
● Aggressive, often death due to disease within 2 years after diagnosis
● Serum AFP may be produced by hepatoid or non-hepatoid bladder carcinomas
Prognostic factors
=========================================================================
●
Case reports
=========================================================================
● 71 year old man (Virchows Arch 1999;435:71)
● 79 year old man (Hinyokika Kiyo 2009;55:619)
Treatment
=========================================================================
●
Clinical images
=========================================================================
●
Gross description (Macroscopy)
=========================================================================
●
Gross images
=========================================================================
Micro description (Histopathology)
=========================================================================
● Large polygonal cells with eosinophilic cytoplasm separated by sinusoids, resembling hepatocellular carcinoma
● Often intracytoplasmic hyaline globules and bile production (Virchows Arch 2003;442:381).
Micro images
=========================================================================
Gastric tumor #1; #2; #3; AFP+
Pancreatic tumor #1; #2-diffuse sheet of poorly differentiated tumor exhibiting abundant, eosinophilic cytoplasm and variably sized cytoplasmic and extracellular Councilman-like bodies (arrows)
Cytology description
=========================================================================
●
Cytology images
=========================================================================
●
Positive stains
=========================================================================
● Alpha-fetoprotein (AFP), alpha-1-antitrypsin, low molecular weight keratin, EMA, pCEA (canalicular pattern)
● Also HEPPAR1, albumin (IHC and mRNA)
Negative stains
=========================================================================
●
Electron microscopy descriptions
=========================================================================
●
Electron microscopy images
=========================================================================
Molecular / cytogenetics description
=========================================================================
●
Molecular / cytogenetics images
=========================================================================
Differential Diagnosis
=========================================================================
● Metastatic carcinoma: either hepatoid adenocarcinoma or hepatocellular carcinoma
Additional references
=========================================================================
●
End of Bladder > Other carcinomas > Hepatoid adenocarcinoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).