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Bladder
Urothelial carcinoma-invasive
Large cell neuroendocrine carcinoma
Reviewer: Rugvedita Parakh, Cedars-Sinai Medical Center, Las Angeles, California
Revised: 11 June 2010, last major update June 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Rare aggressive tumor similar to counterpart in lung
Case reports
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● 32 year old man with aggressive tumor (Pathol Int 2006;56:688)
● 73 year old man with aggressive tumor (Mod Pathol 1998;11:1016)
● 82 year old man whose tumor had small adenocarcinoma component (Arch Pathol Lab Med 2002;126:1229)
● Case with cutaneous metastases (Am J Dermatopathol 2009;31:166)
Micro description (Histopathology)
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● May resemble lung counterpart (Int J Urol 2008;15:1080)
● Either pure or mixed
● Large polygonal cells with low nuclear to cytoplasmic ratio, coarse chromatin, frequent nucleoli, 10+ mitotic figures/10 HPF, multiple areas of necrosis
Micro images
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Various images
Positive stains
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● TTF1, Leu7/CD57, NSE; variable synaptophysin and chromogranin (Am J Clin Pathol 2007;128:733)
Cytology
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● Atypical cells with rosettes and nuclear molding, fine or coarsely granular chromatin, hyperchromasia; positive for synaptophysin (Acta Cytol 2010;54:303)
End of Bladder > Urothelial carcinoma-invasive > Large cell neuroendocrine carcinoma
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