Other carcinomas
Large cell neuroendocrine carcinoma

Author: Rugvedita Parakh, M.D. (see Authors page)

Revised: 15 August 2016, last major update December 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Large cell neuroendocrine carcinoma bladder
Cite this page: Large cell neuroendocrine carcinoma. website. Accessed October 19th, 2018.
Definition / general
  • Rare, aggressive tumor similar to counterpart in lung
  • Combination of histologic (neuroendocrine morphology and necrosis), cytologic (large cell size, abundant cytoplasm, nucleoli, coarse chromatin, high mitotic rate) and imuunohistochemical evidence of neuroendocrine origin
  • Distinguished from atypical carcinoid tumor by necrosis and higher mitotic rate
Case reports
Microscopic (histologic) description
  • Resembles lung counterpart (Int J Urol 2008;15:1080)
  • Either pure or mixed
  • Large polygonal cells with low nuclear to cytoplasmic ratio, coarse chromatin, frequent nucleoli, 10+ mitotic figures/10 HPF, multiple areas of necrosis
Microscopic (histologic) images

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Various images

Positive stains
Cytology description
  • Atypical cells with rosettes and nuclear molding, fine or coarsely granular chromatin, hyperchromasia
  • Average nuclear to cytoplasmic ratio is 1:1.4 (Acta Cytol 2010;54:303)