Urothelial carcinoma-invasive
Large cell undifferentiated carcinoma

Topic Completed: 1 December 2014

Revised: 24 December 2018

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Large cell undifferentiated carcinoma[title]

Rugvedita Parakh, M.D.
Page views in 2018: 611
Page views in 2019 to date: 469
Cite this page: Parakh R Large cell undifferentiated carcinoma. website. Accessed August 18th, 2019.
Definition / general
  • Rare poorly differentiated pleomorphic carcinoma that cannot be otherwise classified
Clinical features
  • Advanced stage at presentation with nodal metastases
  • Poorer survival than urothelial carcinoma NOS of similar stage (Pathology 2010;42:364)
Microscopic (histologic) description
  • Sheets of large polygonal or round cells with moderate to abundant cytoplasm, distinct cell borders
  • Usually 90%+ of tumor is composed of large cell component
  • Tumor is either infiltrative or has solid expansile nests with variable dyscohesive growth
Positive stains
Differential diagnosis
  • Lymphoma: morphology of lymphoma subtype, negative for keratin, positive for lymphocytic markers
  • Melanoma: spindled or epithelioid; prominent nucleoli; positive for melanocytic markers
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