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Urothelial carcinoma-invasive

Lymphoma-like carcinoma

Reviewers: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 3 July 2011, last major update June 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● First described in 1991 (Am J Surg Pathol 1991;15:569)
● Very few cases have been reported


● 80% male; age range 61-76 years

Micro description

● Single, malignant cells in loose or myxoid stroma resembling lymphoma, particularly at biopsy
● Usually areas of high grade urothelial carcinoma
● Often prominent lymphoid infiltrate (usually T cells)

Positive stains

● CK7; variable CK20

Negative stains

Epithelial cells: lymphoid markers

Differential diagnosis

Lymphoepithelioma-like carcinoma: tumor cells appear in syncytium, not as single cells
Lymphoma: no urothelial carcinoma component; positive for lymphoid markers and negative for keratin
Plasmacytoma: associated with myeloma, plasmacytoid cells with abundant cytoplasm and eccentric nuclei, often binucleated forms, no classic urothelial carcinoma, CD38+, CD138+, negative for keratin

End of Bladder > Urothelial carcinoma-invasive > Lymphoma-like carcinoma

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