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Bladder

Urothelial carcinoma-invasive

Lymphoma-like carcinoma

 

Author: Nat Pernick, M.D. (see Authors page)

Revised: 12 June 2010, last major update June 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● First described in 1991 (Am J Surg Pathol 1991;15:569)

● Very few cases have been reported

 

Terminology

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Epidemiology

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● 80% male, age range 61-76 years

 

Sites

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Etiology

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Clinical features

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Prognostic factors

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Case reports

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Treatment

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Clinical images

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Gross description (Macroscopy)

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● 

Gross images

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Micro description (Histopathology)

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● Single malignant cells in loose or myxoid stroma resembling lymphoma, particularly at biopsy

● Usually areas of high grade urothelial carcinoma

● Often prominent lymphoid infiltrate (usually T cells)

 

Micro images

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Cytology description

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Cytology images

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Positive stains

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● CK7; variable CK20

 

Negative stains

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Epithelial cells: lymphoid markers

 

Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Lymphoepithelioma-like carcinoma: tumor cells appear in syncytium, not as single cells

Lymphoma: no urothelial carcinoma component; positive for lymphoid markers, negative for keratin

Plasmacytoma: associated with myeloma, plasmacytoid cells with abundant cytoplasm and eccentric nuclei, often binucleated forms, no classic urothelial carcinoma, CD38+, CD138+, negative for keratin

 

Additional references

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End of Bladder > Urothelial carcinoma-invasive > Lymphoma-like carcinoma

 

 

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