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Bladder
Urothelial carcinoma-invasive
Lymphoma-like carcinoma
Author: Nat Pernick, M.D. (see Authors page)
Revised: 12 June 2010, last major update June 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● First described in 1991 (Am J Surg Pathol 1991;15:569)
● Very few cases have been reported
Terminology
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Epidemiology
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● 80% male, age range 61-76 years
Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Single malignant cells in loose or myxoid stroma resembling lymphoma, particularly at biopsy
● Usually areas of high grade urothelial carcinoma
● Often prominent lymphoid infiltrate (usually T cells)
Micro images
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Cytology description
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Cytology images
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Positive stains
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● CK7; variable CK20
Negative stains
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● Epithelial cells: lymphoid markers
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Lymphoepithelioma-like carcinoma: tumor cells appear in syncytium, not as single cells
● Lymphoma: no urothelial carcinoma component; positive for lymphoid markers, negative for keratin
● Plasmacytoma: associated with myeloma, plasmacytoid cells with abundant cytoplasm and eccentric nuclei, often binucleated forms, no classic urothelial carcinoma, CD38+, CD138+, negative for keratin
Additional references
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End of Bladder > Urothelial carcinoma-invasive > Lymphoma-like carcinoma
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