Urothelial carcinoma-invasive
Lymphoma-like carcinoma

Topic Completed: 1 December 2014

Revised: 24 December 2018

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Lymphoma like carcinoma bladder

Nat Pernick, M.D.
Page views in 2019: 275
Page views in 2020 to date: 14
Cite this page: Pernick N Lymphoma-like carcinoma. website. Accessed January 24th, 2020.
Definition / general
  • 80% male; age range 61-76 years
Microscopic (histologic) description
  • Single, malignant cells in loose or myxoid stroma resembling lymphoma, particularly at biopsy
  • Usually areas of high grade urothelial carcinoma
  • Often prominent lymphoid infiltrate (usually T cells)
Positive stains
Negative stains
  • Epithelial cells: lymphoid markers
Differential diagnosis
  • Lymphoepithelioma-like carcinoma: tumor cells appear in syncytium, not as single cells
  • Lymphoma: no urothelial carcinoma component; positive for lymphoid markers and negative for keratin
  • Plasmacytoma: associated with myeloma, plasmacytoid cells with abundant cytoplasm and eccentric nuclei, often binucleated forms, no classic urothelial carcinoma, CD38+, CD138+, negative for keratin
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