Other carcinomas

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 11 July 2018, last major update December 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Bladder metastases [title]
Cite this page: Roychowdhury, M. Metastases. website. Accessed December 16th, 2018.
Definition / general
  • Most common primaries are breast and melanoma; also lung, pancreas, ovary and stomach
  • Associated with widely disseminated disease
  • Urothelium is usually spared
  • Tumors may also arise from local extension from prostate, uterine cervix or rectum
  • Difficult to distinguish bladder adenocarcinoma morphologically from extension of colonic adenocarcinoma
  • Renal cell metastases: rare (< 40 reported cases); usually men age 35 - 69 years who present with gross hematuria or urinary obstruction if tumor is in bladder neck; metastases also present in other organs; poor prognosis (Mod Pathol 1999;12:351); may be due to hematogenous spread, retrograde spread from renal vein or renal hilar lymphatics or direct intraluminal transit
Case reports
Microscopic (histologic) description
  • Morphology varies based on the primary tumor
  • Metastatic renal cell carcinoma: delicate fibrovascular stroma with abundant sinusoidal vessels; nests of polygonal cells with abundant clear cytoplasm and nuclei ranging from small and hyperchromatic with inconspicuous nucleoli to large irregular nuclei with prominent nucleoli; may resemble urothelial carcinoma with clear cell features
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Metastatic appendiceal
mucinous adenocarcinoma
- various images

Missing Image

Metastatic breast cancer: H&E, PR, HER2

Positive stains
Negative stains
Differential diagnosis
  • Colorectal carcinoma (extension): positive for CK20, villin, beta catenin (nuclear)
  • Prostatic adenocarinoma (extension): positive for PSA, PSAP, AMACR, Leu7
  • Urothelial carcinoma with glandular differentiation: positive for CK7, CK20, 34betaE12, Uroplakin, Thrombomodulin
Additional references