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Bladder
Benign tumors
Neurofibroma
Author: Nat Pernick, M.D. (see Authors page)
Revised: 27 February 2010, last major update February 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Neural tumor similar to counterparts elsewhere
Terminology
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Epidemiology
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● Uncommon
● Presents early in life
● Strongly associated with neurofibromatosis type 1 (Cancer 1999;86:505)
Sites
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Etiology
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Clinical features
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● Plexiform neurofibromas are associated with neurofibromatosis; diffuse neurofibromas are not (Am J Surg Pathol 2008;32:907)
Prognostic factors
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Case reports
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● 6 year old girl with neurofibromatosis-1, bladder plexiform neurofibroma and diffuse ganglioneuromatosis of bladder (Hum Pathol 2008;39:1708)
● 18 year old man with neurofibromatosis-1 (Radiographics 2004;24 Suppl 1:S237)
Treatment
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Clinical images
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Gross description (Macroscopy)
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● Polypoid or diffuse
Gross images
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Plexiform neurofibroma
M: bladder mucosa
Arrows: ureteric orifice
Micro description (Histopathology)
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Micro images
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Lamina propria shows meissner-type Bland spindled cells in fibrous stroma
corpuscles
Plexiform neurofibroma Various images
Fig A: Diffuse and plexiform growth Increased cellularity
Fig B: Neurofilament staining
Fig C: Ganglion cells within neurofibroma
Fig D: S100+
Fig E: Strong neurofilament staining
Fig F: Submucosal tissue involvement
Other images: replacement of bladder wall #1; #2
Cytology description
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Cytology images
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Positive stains
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● S100
Negative stains
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● Keratin, smooth muscle actin, desmin, calponin, caldesmon
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Bladder > Benign tumors > Neurofibroma
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