Bladder
Urothelial carcinoma-invasive
Plasmacytoid carcinoma

Author: Plasmacytoid carcinoma, M.D., Rugvedita Parakh, M.D. (see Authors page)

Revised: 19 July 2016, last major update December 2014

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PubMed Search: Plasmacytoid carcinoma
Cite this page: Plasmacytoid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladderplasmacytoidcarcinoma.html. Accessed December 3rd, 2016.
Definition / General
  • Urothelial carcinoma in which tumor cells have features of plasma cells, due to abundant glassy eosinophilic cytoplasm, eccentric nuclei and indistinct nucleoli
  • Included in the WHO classification since 2004
Clinical Features
  • Rare
  • Tends to present at advanced stage with poor prognosis
  • Diagnosed at advanced pathological stage (64% pT3, 23% pT4), showing metastases in 60% (Int J Cancer 2011;129:346)
  • May spread in abdominal cavity more commonly than other variants
Case Reports
Micro Description
  • Urothelial tumor cells resemble plasma cells, due to abundant glassy eosinophilic cytoplasm and eccentric nuclei
  • Discohesive single cell pattern resembling lobular breast carcinoma or diffuse type of gastric cancer
  • Myxoid or loose edematous stroma
  • Retraction spaces around tumor cells
  • Classic urothelial carcinoma usually also present
Micro Images

Images hosted on other servers:

Various images

Keratin+

Keratin+ nodal metastasis

Cytology Description
  • Scattered discohesive cells with a plasmacytoid appearance, characterized by abundant cytoplasm, eccentric nuclei and inconspicuous nucleoli (Diagn Cytopathol 2009;37:359)
Positive Stains
Negative Stains
  • Plasma cell and lymphocyte markers, gamma globulin, light chains
  • Membranous E-cadherin (usually)
Molecular / Cytogenetics Description
  • Highly aneuploid and polysomic
  • Deletion on chromosome 9p21 is common
  • p53 mutation in 29%
Differential Diagnosis
  • Plasmacytoma: often associated with myeloma, no usual type urothelial carcinoma, tumor cells have plasmacytic features, are keratin-
  • Metastatic lobular breast carcinoma: ER/PR positive, GCDFP 15 or mammoglobin positive, always E-cadherin negative, no usual type urothelial carcinoma
Additional References