Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Bladder

Other tumors

Plasmacytoma


Reviewers: Gillian Levy, M.D., Yale Medical Center Reviewers page)
Last Revised: 13 June 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Neoplastic proliferation of plasma cells; may be associated with multiple myeloma
● Plasma cell neoplasm composed of plasma cells in any stage of differentiation

Epidemiology
=========================================================================

● Rare in bladder

Etiology
=========================================================================

● Most patients have known multiple myeloma or develop multiple myeloma

Clinical features
=========================================================================

● Tumors look and act like solid tumors
● May be associated with serum and urine monoclonal immunoglobulins
● May recur, usually donít cause death

Case reports
=========================================================================

● 36 year old woman with post-transplantation tumor (Int J Hematol 2005;81:255)
● 95 year old woman with bladder mass (Acta Cytol 2006;50:339)

Gross description (Macroscopy)
=========================================================================

● Single or nodular mass of bladder wall

Micro description (Histopathology)
=========================================================================

● Mature and immature plasmacytoid forms, including giant cells
● Tumor cells have typical plasma cell morphology with eccentric nuclei and perinuclear hoffs or can be atypical with giant cells

Micro images
=========================================================================



Plasmacytoma

           
Tumors (left to right) of adrenal gland, nasopharynx, lung, testis


Kappa light chain staining

Cytology description
=========================================================================

● Urine histiocytes may contain immunoglobulin crystals (Diagn Cytopathol 2004;31:48)

Cytology images
=========================================================================


   
Touch prep (left to right): lymph node/spleen; nasopharynx

Positive stains
=========================================================================

● CD138+, weakly positive for CD20 and CD45RB, variably positive for EMA; may express IgA or IgM
● Restricted light chain expression (kappa or lambda but not both)

Negative stains
=========================================================================

● Keratin

Electron microscopy images
=========================================================================



Stomach tumor: Russell bodies consist of numerous cytoplasmic granules composed of aggregates of membranes

Differential Diagnosis
=========================================================================

Plasmacytoid urothelial carcinoma: usually advanced stage with nodal metastases, areas of classic urothelial carcinoma, small intracytoplasmic vacuoles, keratin+ (CK7, AE1-AE3, CAM5.2), variable CK20, often CD138+ (Hum Pathol 2009;40:1023, Am J Surg Pathol 2009;33:417)
Malignant lymphoma: B cell tumors are CD20+, only weakly positive or negative for kappa or lambda, and variable positivity for CD138

Additional references
=========================================================================

eMedicine

End of Bladder > Other tumors > Plasmacytoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).