Bladder
Other tumors
Plasmacytoma

Author: Gillian Levy, M.D. (see Authors page)

Revised: 9 August 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Bladder plasmacytoma
Definition / General
  • Neoplastic proliferation of plasma cells; may be associated with multiple myeloma
  • Plasma cell neoplasm composed of plasma cells in any stage of differentiation
Epidemiology
  • Rare in bladder
Etiology
  • Most patients have known multiple myeloma or develop multiple myeloma
Clinical Features
  • Tumors look and act like solid tumors
  • May be associated with serum and urine monoclonal immunoglobulins
  • May recur, usually don’t cause death
Case Reports
Gross Description
  • Single or nodular mass of bladder wall
Micro Description
  • Mature and immature plasmacytoid forms, including giant cells
  • Tumor cells have typical plasma cell morphology with eccentric nuclei and perinuclear hoffs or can be atypical with giant cells
Micro Images

Images hosted on other servers:
Missing Image

Tumors (left to right) of adrenal gland, nasopharynx, lung, testis

Cytology Description
Positive Stains
  • CD138+, weakly positive for CD20 and CD45RB, variably positive for EMA; may express IgA or IgM
  • Restricted light chain expression (kappa or lambda but not both)
Negative Stains
  • Keratin
Differential Diagnosis
Additional References