Acquired non-neoplastic anomalies
Pseudocarcinomatous epithelial hyperplasia

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 March 2016, last major update June 2011

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Pseudocarcinomatous epithelial hyperplasia
Definition / General
Clinical Features
  • Associated with radiation therapy; also ischemia and chronic irritation
  • No treatment is required for this reactive condition
Case Reports
Micro Description
  • Downward proliferation of urothelial pseudoinvasive nests with focal squamous metaplasia but without atypia
  • Nests wrap around vessels with fibrin deposition and congestion
  • May have retraction artifact
  • These nests, especially because of their irregular shape, can resemble invasive carcinoma; however, morphology is not typical of early invasive urothelial carcinoma
  • Frequently hemorrhage, thickened vessels and other radiation associated vascular changes are present
  • Fibrin deposition, fibrin thrombi, fibrosis, inflammation, hemosiderin, ulceration, edema and vascular congestion
  • No mitotic figures
Micro Images

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Case of the Week #198

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Pseudocarcinomatous proliferation related to radiation therapy