Bladder & ureters
Acquired nonneoplastic anomalies
Pseudocarcinomatous epithelial hyperplasia


Topic Completed: 1 June 2011

Revised: 13 June 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Pseudocarcinomatous epithelial hyperplasia

Nat Pernick, M.D.
Page views in 2018: 617
Page views in 2019 to date: 570
Cite this page: Pernick N. Pseudocarcinomatous epithelial hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladderpseudocarcinoma.html. Accessed August 25th, 2019.
Definition / general
Clinical features
  • Associated with radiation therapy; also ischemia and chronic irritation
  • No treatment is required for this reactive condition
Case reports
Microscopic (histologic) description
  • Downward proliferation of urothelial pseudoinvasive nests with focal squamous metaplasia but without atypia
  • Nests wrap around vessels with fibrin deposition and congestion
  • May have retraction artifact
  • These nests, especially because of their irregular shape, can resemble invasive carcinoma; however, morphology is not typical of early invasive urothelial carcinoma
  • Frequently hemorrhage, thickened vessels and other radiation associated vascular changes are present
  • Fibrin deposition, fibrin thrombi, fibrosis, inflammation, hemosiderin, ulceration, edema and vascular congestion
  • No mitotic figures
Microscopic (histologic) images

Case of the Week #198

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