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Bladder

Other tumors

Rhabdoid tumor


Reviewers: Gillian Levy, M.D., Yale Medical Center (see Reviewers page)
Revised: 30 April 2011, last major update April 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Controversial tumor of bladder - a few unequivocal cases in children / teenagers have been described

Epidemiology
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● Very rare

Clinical features
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● Patients present with hematuria
● Poor prognosis

Micro description (Histopathology)
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● Large rhabdoid cells with abundant brightly eosinophilic cytoplasm, vesicular nuclei and a prominent nucleolus in a myxoid background
● Cases with prominent rhabdoid component usually have other carcinoma components (Hum Pathol 2006;37:168, free text)

Micro images
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Fig. 1/2: large rhabdoid cells with abundant cytoplasm and prominent nucleoli

           
Renal rhabdoid tumor

Positive stains
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● Keratin (EMA, CAM 5.2, AE1-AE3) focally positive, vimentin positive

Electron microscopy description
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● Intermediate filaments adjacent to nucleus

Electron microscopy images
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Kidney: whorled aggregates of intermediate filaments

Differential diagnosis
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Neuroblastoma: also rare at this site, small blue cell tumor

End of Bladder > Other tumors > Rhabdoid tumor


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