Bladder & ureters
Benign tumors
Solitary fibrous tumor


Topic Completed: 1 December 2014

Revised: 21 June 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Bladder [title] Solitary fibrous tumor

Monika Roychowdhury, M.D.
Page views in 2018: 331
Page views in 2019 to date: 207
Cite this page: Roychowdhury M. Solitary fibrous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladdersolitary.html. Accessed August 18th, 2019.
Definition / general
  • Rare tumor in bladder, similar to counterparts elsewhere
Epidemiology
  • Men ages 50 - 67 years
  • < 50 cases reported
Clinical features
  • Often misdiagnosed (Hum Pathol 2000;31:63)
  • Benign behavior (usually)
  • Slow growing, painless, well-delineated mass, may lead to compression symptoms
  • Rarely causes paraneoplastic syndrome (hypoglycemia secondary to insulin-like growth factor, known as Doege-Potter Syndrome)
Prognostic factors
  • Unpredictable behavior
  • Malignant transformation and large size associated with poor outcome
  • Atypical cytologic features, increased mitotic activity (>4/10hpf), size >10cm and resectability are important prognostic factors to predict recurrence or metastatic behavior
Case reports
Treatment
  • Excision, usually do not recur but follow up recommended
Gross description
  • Often very large, well-circumscribed, tan-colored mass which often has a pedicle
Gross images

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Well circumscribed tumors

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Solid, tan, fibrotic tumor

Microscopic (histologic) description
  • Resembles pleural counterpart: haphazard (patternless) spindle cells with hypo- and hypercellular areas, and deposition of dense collagen
  • Spindly to oval epithelioid cells form short fascicles or clusters
  • May have hemangiopericytoma-like vascular pattern
  • Generally scarce mitoses - usually less than 3 mitoses per 10 high power fields
Microscopic (histologic) images

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Plump spindled cells with prominent vasculature

Differential diagnosis
  • Sarcoma
  • Sarcomatoid carcinoma
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