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Bladder
Benign tumors
Solitary fibrous tumor
Author: Nat Pernick, M.D. (see Authors page)
Revised: 28 February 2010, last major update February 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Rare tumor in bladder, similar to counterparts elsewhere
Terminology
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Epidemiology
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● Men ages 50-67 years
● < 50 cases reported
Sites
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Etiology
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Clinical features
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● Often misdiagnosed (Hum Path 2000;31:63)
● Benign behavior
Prognostic factors
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Case reports
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● 24 year old woman (Eur Urol 2008;54:1188)
● 50 year old man with hematuria (Eur Urol 2001;39:484)
● 60 year old man with bladder wall mass (Int Braz J Urol 2004;30(5))
Treatment
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● Excision (partial or complete cystectomy), usually does not recur but follow up recommended
Clinical images
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Gross description (Macroscopy)
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● Often very large
Gross images
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Well circumscribed tumor Solid, tan, fibrous tumor
Micro description (Histopathology)
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● Resembles pleural counterpart - haphazard (patternless) spindle cells with hypo- and hypercellular areas, and deposition of dense collagen
● May have hemangiopericytoma-like vascular pattern
Micro images
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Plump spindled cells with Short spindle cells with delicate CD34+
prominent vasculature cytoplasm, no atypia
Cytology description
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Cytology images
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Positive stains
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● CD34 (Hum Path 1997;28:1204), bcl2, vimentin
Negative stains
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● Cytokeratin, EMA, smooth muscle markers
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Sarcoma
● Sarcomatoid carcinoma
Additional references
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End of Bladder > Benign tumors > Solitary fibrous tumor
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