Bladder, ureter & renal pelvis
Xanthogranulomatous cystitis

Topic Completed: 1 June 2016

Minor changes: 20 June 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Xanthogranulomatous [title] cystitis

Turki Al-Hussain, M.D.
Page views in 2019: 651
Page views in 2020 to date: 635
Cite this page: Al-Hussain T. Xanthogranulomatous cystitis. website. Accessed October 24th, 2020.
Definition / general
  • Rare (<50 cases reported in bladder) inflammatory disorder characterized by lipid-laden macrophages
Clinical features
  • Benign, but associated with malignancy in some cases (Histopathology 1998;33:212)
  • Associated with xanthogranulomatous pyelonephritis, urachal adenomas, inflammatory bowel disease
Case reports
  • Broad spectrum antibiotics; possibly resection
Microscopic (histologic) description
  • Lipid-laden macrophages, plasma cells and lymphocytes
  • May have some Touton-type giant cells
  • Similar to malakoplakia but without Michaelis-Gutmann bodies
Microscopic (histologic) images

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Lamina propria contains sheets of lipid-laden macrophages

Positive stains
Negative stains
Differential diagnosis
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