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Bladder
Cystitis
Xanthogranulomatous cystitis
Author: Nat Pernick, M.D. (see Authors page)
Revised: 24 December 2009, UPDATE IN PROGRESS
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Rare; < 50 cases reported
Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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● Benign, but associated with malignancy in some cases (Histopathology 1998;33:212)
● Associated with xanthogranulomatous pyelonephritis, urachal adenomas
Prognostic factors
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Case reports
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● 50 year old man with multiple small polypoidal growths (Int Urol Nephrol 2007;39:477)
● 76 year old man with painless hematuria and bladder mass (Int Urogynecol J Pelvic Floor Dysfunct 2007;18:1233)
Treatment
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● Broad spectrum antibiotics; possibly resection
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Lipid-laden macrophages, plasma cells and lymphocyte; may have some Touton-type giant cells
● Similar to malakoplakia but without Michaelis-Gutmann bodies
Micro images
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Lamina propria contains sheets of lipid-laden macrophages
Xanthogranulomatous pyelonephritis
Cytology description
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Cytology images
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Positive stains
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● CD68 (macrophages)
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Malakoplakia: has Michaelis-Gutmann bodies
Additional references
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End of Bladder > Cystitis > Xanthogranulomatous cystitis
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