Xanthogranulomatous cystitis

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 7 June 2016, last major update June 2016

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Xanthogranulomatous [title] cystitis
Cite this page: Xanthogranulomatous cystitis. website. Accessed December 11th, 2018.
Definition / general
  • Rare (<50 cases reported in bladder) inflammatory disorder characterized by lipid-laden macrophages
Clinical features
  • Benign, but associated with malignancy in some cases (Histopathology 1998;33:212)
  • Associated with xanthogranulomatous pyelonephritis, urachal adenomas, inflammatory bowel disease
Case reports
  • Broad spectrum antibiotics; possibly resection
Microscopic (histologic) description
  • Lipid-laden macrophages, plasma cells and lymphocytes
  • May have some Touton-type giant cells
  • Similar to malakoplakia but without Michaelis-Gutmann bodies
Microscopic (histologic) images

Images hosted on other servers:

Lamina propria contains sheets of lipid-laden macrophages

Positive stains
Negative stains
Differential diagnosis