Bone & joints
Fibrogenic / fibrohistiocytic tumors
Benign fibrous histiocytoma

Topic Completed: 1 June 2005

Minor changes: 11 July 2019

Copyright: 2003-2019,, Inc.

PubMed search: benign fibrous histiocytoma [title] bone

Nat Pernick, M.D.
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Cite this page: Pernick N. Benign fibrous histiocytoma. website. Accessed November 30th, 2020.
Definition / general
  • Very uncommon
  • Usually older than 20 years
  • Associated with pain
  • Benign behavior
  • Sites: pelvic bones, other unusual sites
Radiology description
  • Small, lytic lesions with sharply defined margins and a sclerotic rim
Case reports
  • Curettage and bone grafting, may recur locally
Microscopic (histologic) description
  • Storiform pattern of spindled cells with frequent foam cells and variable benign multinucleated giant cells
  • Resembles cutaneous counterpart
Microscopic (histologic) images

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Foam cells with delicate fibrous stroma and reactive bone

Cytology description
  • Scattered foam cells, minimal inflammatory infiltrate, no mitotic activity
Differential diagnosis
Additional references
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