Bone
Other tumors of bone
Benign notochordal cell tumors

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: benign notochordal cell tumor

Cite this page: Benign notochordal cell tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneBNCT.html. Accessed December 7th, 2016.
Definition / General
  • Intraosseous tumors - not notochordal rest or hamartoma
  • At autopsy, found in 14% of spinal columns and 11.5% of clivi, usually ages 40+ years, often multiple
Treatment
  • Followup but no surgery
  • May undergo malignant transformation to classic chordomas
Gross Description
  • Usually small within axial bones, rarely involve entire vertebrae
Micro Description
  • Well demarcated but unencapsulated
  • Sheets of adipocyte-like vacuolated or eosinophilic cells with fewer vacuoles
  • Often cytoplasmic eosinophilic hyaline globules
  • Bland round nuclei with mild pleomorphism
  • May contain colloid-like material
  • Bone trabeculae often sclerotic but no bony destruction
  • No intercellular myxoid matrix, no necrosis, no mitotic figures
Micro Images
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Benign notochordal cell tumor

Positive Stains
  • PAS+ diastase resistant eosinophilic hyaline globules
Differential Diagnosis
  • Chordoma: osteolytic, lobules are separate by thin fibrous septa, lobules contain cords, strands or sheets of physaliphorous cells with myxoid matrix, cells have mild to marked nuclear atypia
  • Notochordal vestiges: cords or strands of notochordal cells within myxoid background, cells have eosinophilic cytoplasm with small vacuoles, pyknotic round nuclei, CK18 negative, usually replaced by fibrocartilage by age 1 - 3 years
Additional References