Bone & joints
Other tumors
Inflammatory myofibroblastic tumor

Topic Completed: 1 June 2005

Minor changes: 11 July 2019

Copyright: 2003-2019,, Inc.

PubMed search: inflammatory myofibroblastic tumor [title] bone

Nat Pernick, M.D.
Page views in 2019: 245
Page views in 2020 to date: 230
Cite this page: Pernick N. Inflammatory myofibroblastic tumor. website. Accessed September 29th, 2020.
Definition / general
  • Also called inflammatory fibrosarcoma or inflammatory pseudotumor
  • Very rare in bone
Radiology description
  • Destructive bone tissue that expands into soft tissue
Radiology images

Images hosted on other servers:

Osteolytic lesion with
irregular margin and
sclerotic rim, extend-
ing into soft tissue

Case reports
Gross description
  • Solitary, well demarcated, grayish yellow tumor, may expand into adjacent soft tissue
Microscopic (histologic) description
  • Cellular area with fascicles composed of thin spindle cells with eosinophilic cytoplasm, mild pleomorphism, frequent normal mitotic figures and infiltrate of lymphocytes and plasma cells
  • Hypocellular fibrous area with minimal inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Fascicular, storiform and hypocellular areas

Alpha smooth muscle actin

Negative stains
Molecular / cytogenetics description
  • May be neoplastic
Differential diagnosis
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