Other tumors of bone
Inflammatory myofibroblastic tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 19 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: inflammatory myofibroblastic tumor [title] bone

Cite this page: Inflammatory myofibroblastic tumor. website. Accessed September 24th, 2018.
Definition / general
  • Also called inflammatory fibrosarcoma or inflammatory pseudotumor
  • Very rare in bone
Radiology description
  • Destructive bone tissue that expands into soft tissue
Radiology images
Images hosted on other servers:

Osteolytic lesion with
irregular margin and
sclerotic rim, extend-
ing into soft tissue

Case reports
Gross description
  • Solitary, well demarcated, grayish yellow tumor, may expand into adjacent soft tissue
Microscopic (histologic) description
  • Cellular area with fascicles composed of thin spindle cells with eosinophilic cytoplasm, mild pleomorphism, frequent normal mitotic figures and infiltrate of lymphocytes and plasma cells
  • Hypocellular fibrous area with minimal inflammatory cells
Microscopic (histologic) images
Images hosted on other servers:

Fascicular, storiform and hypocellular areas

Alpha smooth muscle actin

Negative stains
Molecular / cytogenetics description
  • May be neoplastic
Differential diagnosis