Bone
Other tumors of bone
Leiomyosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: leiomyosarcoma [title] bone

Cite this page: Leiomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneLMS.html. Accessed December 2nd, 2016.
Definition / General
  • Very rare as primary tumor of bone, resembles soft tissue counterpart
  • Mean age 44 years, range 13 - 77 years; no gender preference
  • Often jaw, femur or other long bones
  • May occur post radiation therapy
  • 75% high grade, predicts recurrence and metastases
Micro Images
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Quiz case

Positive Stains
Negative Stains
  • p53 (usually)
Electron Microscopy Description
  • Cytoplasmic microfilaments with focal densities
Differential Diagnosis