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Malignant fibrous histiocytoma (MFH)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2005

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PubMed search: malignant fibrous histiocytoma [title] bone

Related topics: diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMS-MFH)

Table of Contents
Definition / general | Radiology images | Gross images | Microscopic (histologic) images
Cite this page: Malignant fibrous histiocytoma (MFH). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneMFH.html. Accessed July 14th, 2017.
Definition / general
  • Mean age 34 - 40 years but all ages, no gender predominance
  • Sites: metaphysis of long bones, jaw
  • Associated with bone infarcts (30%), foreign bodies, radiation (15%, Am J Surg Pathol 1986;10:9), Paget disease, dedifferentiation or transformation of chondrosarcoma, chordoma or giant cell tumor
  • Behaves like a high grade sarcoma with a poor prognosis, particularly for older patients and secondary sarcomas
  • Five year survival of 78% if prominent chronic inflammatory infiltrate
Radiology images
Images hosted on PathOut server:

Primary, distal femur - contributed by Dr. Mark R. Wick

Radiograph of tibial tumor

Gross images
Images hosted on PathOut server:

Primary - contributed by Dr. Mark R. Wick

Microscopic (histologic) images
Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Primary - contributed by Dr. Mark R. Wick

Mixture of malignant fibroblasts and histiocytes

Fibroblasts dominate


Irregular deposits of noncalcified collagen

Broad area of collagen deposits is sparsely cellular

Markedly vascular tumor

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