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Table of Contents
Definition / general | Radiology description | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy description | Differential diagnosis | Additional referencesCite this page: Angiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneangiosarcoma.html. Accessed July 14th, 2017.
Definition / general
- Also called hemangioendothelioma in bone, although angiosarcomas have more cytologic atypia
- Rare; may be multicentric
- 1 / 3 affect long tubular bones, but any bone may be affected
- 1 / 3 are multifocal, usually in one geographic area, such as an entire leg
- After diagnosis, search for multicentricity
- Distant metastases common, often to lungs
- Graded 1 - 3 based on atypia of endothelial cells
- Grade 1 have excellent prognosis vs. poor prognosis for grade 3
Radiology description
- Lytic areas of destruction, with minimal / no reactive new bone formation
Gross description
- Red, hemorrhagic
Gross images
Images hosted on PathOut server:
Primary bone multifocal - contributed by Dr. Mark R. Wick
Microscopic (histologic) description
- Obvious atypia of tumor cells, solid areas alternating with irregular, anastomosing vascular channels
- Necrosis and hemorrhage, brisk mitotic activity
- Variable differentiation often within same tumor; may be epithelioid or histiocytic
- May have benign giant cells, eosinophils, occasionally reactive bone formation
Microscopic (histologic) images
Images hosted on PathOut server:
Grade 3
Primary bone - contributed by Dr. Mark R. Wick
Positive stains
Electron microscopy description
- Endothelial cell features, may have pericytic features
Differential diagnosis
Additional references
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