Vascular tumors of bone

Topic Completed: 1 June 2005

Revised: 2 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed search: angiosarcoma [title] bone

Related topics: Epithelioid angiosarcoma

Nat Pernick, M.D.
Page views in 2018: 429
Page views in 2019 to date: 423
Cite this page: Pernick N Angiosarcoma. website. Accessed October 13th, 2019.
Definition / general
  • Also called hemangioendothelioma in bone, although angiosarcomas have more cytologic atypia
  • Rare; may be multicentric
  • 1 / 3 affect long tubular bones, but any bone may be affected
  • 1 / 3 are multifocal, usually in one geographic area, such as an entire leg
  • After diagnosis, search for multicentricity
  • Distant metastases common, often to lungs
  • Graded 1 - 3 based on atypia of endothelial cells
  • Grade 1 have excellent prognosis vs. poor prognosis for grade 3
Radiology description
  • Lytic areas of destruction, with minimal / no reactive new bone formation
Gross description
  • Red, hemorrhagic
Gross images

Contributed by Dr. Mark R. Wick

Primary bone multifocal

Microscopic (histologic) description
  • Obvious atypia of tumor cells, solid areas alternating with irregular, anastomosing vascular channels
  • Necrosis and hemorrhage, brisk mitotic activity
  • Variable differentiation often within same tumor; may be epithelioid or histiocytic
  • May have benign giant cells, eosinophils, occasionally reactive bone formation
Microscopic (histologic) images

Grade 3

Contributed by Dr. Mark R. Wick

Primary bone

Electron microscopy description
  • Endothelial cell features, may have pericytic features
Additional references
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