Vascular tumors of bone
Epithelioid angiosarcoma

Topic Completed: 1 June 2005

Revised: 9 November 2019

Copyright: (c) 2003-2019,, Inc.

PubMed search: epithelioid angiosarcoma [title] bone

Related topics: Angiosarcoma

Nat Pernick, M.D.
Page views in 2018: 1,779
Page views in 2019 to date: 2,146
Cite this page: Pernick, N. Epithelioid angiosarcoma. website. Accessed November 15th, 2019.
Definition / general
  • 80% male, mean age 62 years, range 26 - 83 years
  • 60% multifocal
  • Aggressive clinical course
  • > 90% of tumor cells have epithelioid features
Radiology images

Images hosted on PathOut server:

Primary bone Xray - contributed by Dr. Mark R. Wick

Case reports
Gross description
  • Friable, hemorrhagic, destructive tumor, 2 cm - 12 cm
  • Poorly defined, infiltrates medullary canal, frequently erodes cortex and invades adjacent soft tissue
Microscopic (histologic) description
  • Solid and infiltrative sheets replacing the marrow and encasing bony trabeculae
  • No lobular growth pattern
  • Usually with prominent vascular channels or cystically dilated spaces
  • Tumor cells are large, polygonal with abundant eosinophilic cytoplasm, large nuclei with open chromatin, prominent eosinophilic nuclei
  • Frequent intratumoral hemorrhage, neutrophils, intracytoplasmic lumina
  • Frequent mitotic figures and necrosis
  • May have rhabdoid or spindled features
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Primary bone - contributed by Dr. Mark R. Wick

Positive stains
Negative stains
Electron microscopy description
  • Long junctions, intracytoplasmic filaments, mitochondria, rough endoplasmic reticulum
  • May contain rare Weibel-Palade bodies
Differential diagnosis
  • Metastatic carcinoma: no well formed vascular channels, no neutrophils; negative for factor VIII, CD31 and CD34
  • Mucin+ cytoplasmic vacuoles
Additional references
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