Other tumors of bone
Brown tumor of hyperparathyroidism

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: brown tumor hyperparathyroidism [title] bone

Cite this page: Brown tumor of hyperparathyroidism. website. Accessed October 20th, 2018.
Definition / general
  • Solitary or multiple
  • Resect parathyroid tumor causing hyperparathyroidism or control hypophosphatemia medically (tumor rapidly regresses)
Gross description
  • Large lytic lesion resembling bone tumor
  • Brown due to hemorrhage
Microscopic (histologic) description
  • Numerous giant cells with interstitial hemorrhage, hemosiderin, microfractures, ingrowth of vascularized fibrous tissue with fibroblasts
Differential diagnosis
  • Giant cell granuloma: different clinical history and laboratory findings
  • Giant cell tumor: more uniformly distributed giant cells, no interstitial hemorrhage, no fibroblastic stromal cells