Other tumors of bone
Brown tumor of hyperparathyroidism

Topic Completed: 1 June 2005

Revised: 2 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed search: brown tumor hyperparathyroidism [title] bone

Nat Pernick, M.D.
Page views in 2019: 5,047
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Cite this page: Pernick N Brown tumor of hyperparathyroidism. website. Accessed May 31st, 2020.
Definition / general
  • Solitary or multiple
  • Resect parathyroid tumor causing hyperparathyroidism or control hypophosphatemia medically (tumor rapidly regresses)
Gross description
  • Large lytic lesion resembling bone tumor
  • Brown due to hemorrhage
Microscopic (histologic) description
  • Numerous giant cells with interstitial hemorrhage, hemosiderin, microfractures, ingrowth of vascularized fibrous tissue with fibroblasts
Differential diagnosis
  • Giant cell granuloma: different clinical history and laboratory findings
  • Giant cell tumor: more uniformly distributed giant cells, no interstitial hemorrhage, no fibroblastic stromal cells
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