Brown tumor of hyperparathyroidism

Bone
Other tumors of bone
Brown tumor of hyperparathyroidism

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 October 2016, last major update June 2005

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PubMed search: brown tumor hyperparathyroidism [title] bone

Table of Contents

Definition / general | Treatment | Gross description | Microscopic (histologic) description | Differential diagnosis

Cite this page: Brown tumor of hyperparathyroidism. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonebrowntumor.html. Accessed July 14th, 2017.

Definition / general

Solitary or multiple

Treatment

Resect parathyroid tumor causing hyperparathyroidism or control hypophosphatemia medically (tumor rapidly regresses)

Gross description

Large lytic lesion resembling bone tumor
Brown due to hemorrhage

Microscopic (histologic) description

Numerous giant cells with interstitial hemorrhage, hemosiderin, microfractures, ingrowth of vascularized fibrous tissue with fibroblasts

Differential diagnosis

Giant cell granuloma: different clinical history and laboratory findings
Giant cell tumor: more uniformly distributed giant cells, no interstitial hemorrhage, no fibroblastic stromal cells