Chondrogenic tumors
Juxtacortical (periosteal) chondroma

Topic Completed: 1 August 2013

Minor changes: 31 October 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Juxtacortical (periosteal) chondroma

Nat Pernick, M.D.
Page views in 2019: 1,371
Page views in 2020 to date: 751
Cite this page: Pernick N. Juxtacortical (periosteal) chondroma. website. Accessed May 26th, 2020.
Definition / general
  • Rare
  • Usually 3 cm or less
  • Surface of long bone or small bones of hand / feet
  • Usually teens to twenties, more common in males
  • Sites: metaphysis or shaft of tubular bones; may arise in zones lacking periosteum such as the femoral neck
Radiology description
  • Well defined, 2 - 4 cm, sharply scallops outer cortex of underlying bone
Radiology images

AFIP images

Periosteal chondroma

  • Excision
  • May recur if incompletely excised
Case reports
Gross description
  • Single periosteal mass, often with internal calcifications
Gross images

AFIP images

Periosteal chondroma

 Contributed by Dr. Mark R. Wick


Microscopic (histologic) description
  • Benign hyaline cartilage tumor covered by periosteum or reactive bone
  • Hypercellular with variable myxoid features and binucleation
  • Does not invade surrounding tissue, no mitotic figures
Microscopic (histologic) images

AFIP images

Periosteal chondroma

Images hosted on other servers

Xray, H&E

Differential diagnosis

Images hosted on Pathout server:
  • Periosteal chondrosarcoma: patients in 30’s, larger size, infiltrates soft tissues, aggressive appearance on Xray, similar histology
  • Periosteal osteosarcoma: osteoid and spindle shaped malignant cells
  • Additional references
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