Bone
Chondrosarcoma
General



Topic Completed: 1 June 2005

Revised: 31 December 2018

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed search: chondrosarcoma [title] bone


Nat Pernick, M.D.
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Cite this page: Pernick N Chondrosarcoma - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonechondrosarcoma.html. Accessed June 19th, 2019.
Definition / general
  • Malignant cartilage forming tumor that does not produce osteoid
  • May arise from osteochondroma
  • Third most common bone malignancy after myeloma and osteosarcoma
  • Divided into conventional (central, peripheral, juxtacortical / periosteal) and variants (clear cell, dedifferentiation, mesenchymal, myxoid)
  • Higher levels of platelet derived growth factor isoform AA and PDGF-alpha receptor are present in chondrosarcomas vs. enchondromas / mature joint cartilage; higher levels also in high grade vs. low grade chondrosarcoma (Am J Surg Pathol 2001;25:1520)
Radiology images

Contributed by Dr. Mark R. Wick:

CT scan

Distal femur Xray

Femur Xray

Scapula Xray



AFIP images:

Central chondrosarcoma

Pubic symphysis

Scapula

Gross images

Contributed by Dr. Mark R. Wick:

Grade 1 pubis

Proximal femur



AFIP images:

Rib

Lobular configuration

Intramedullary tumor

Knobby appearance

Juxtacortical chondrosarcoma

Microscopic (histologic) images

Contributed by Dr. Mark R. Wick:

Grade 1

Grade 2


Hyaline type grade 1

Hyaline type grade 2

Hyaline type grade 3

Invading bone



AFIP images:

Well differentiated

Grade 1

Grade 1

Grade 1


Grade 2

Grade 2

Grade 3


Spindle cells

Reactive new bone

Edge infiltrates bone marrow

Penetrates cortex

Multinucleated stellate cell

Juxtacortical chondrosarcoma

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