Bone
Chondrosarcoma
General

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: chondrosarcoma [title] bone

Cite this page: Chondrosarcoma - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonechondrosarcoma.html. Accessed December 6th, 2016.
Definition / General
  • Malignant cartilage forming tumor that does not produce osteoid
  • May arise from osteochondroma
  • Third most common bone malignancy after myeloma and osteosarcoma
  • Divided into conventional (central, peripheral, juxtacortical / periosteal) and variants (clear cell, dedifferentiation, mesenchymal, myxoid)
  • Higher levels of platelet derived growth factor isoform AA and PDGF-alpha receptor are present in chondrosarcomas vs. enchondromas / mature joint cartilage; higher levels also in high grade vs. low grade chondrosarcoma (Am J Surg Pathol 2001;25:1520)
Radiology Images
Images hosted on PathOut server:

CT scan - contributed by Dr. Mark R. Wick

Distal femur xray - contributed by Dr. Mark R. Wick

Femur xray - contributed by Dr. Mark R. Wick

Scapula xray - contributed by Dr. Mark R. Wick


Central chondrosarcoma

Pubic symphysis

Scapula

Gross Images
Images hosted on PathOut server:

Grade 1 pubis - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Proximal femur - contributed by Dr. Mark R. Wick

Rib


Lobular configuration

Intramedullary tumor

Knobby appearance

Juxtacortical chondrosarcoma

Micro Images
Images hosted on PathOut server:

Grade 1 - contributed by Dr. Mark R. Wick

Well differentiated

Grade 2 - contributed by Dr. Mark R. Wick


Hyaline type grade 1 - contributed by Dr. Mark R. Wick

Hyaline type grade 2 - contributed by Dr. Mark R. Wick

Hyaline type grade 3 - contributed by Dr. Mark R. Wick

Invading bone - contributed by Dr. Mark R. Wick


Grade 1

Grade 1

Grade 1


Grade 2

Grade 2

Grade 3


Spindle cells

Reactive new bone

Edge infiltrates bone marrow

Penetrates cortex

Multinucleated stellate cell

Juxtacortical chondrosarcoma