Bone
Chondrosarcoma
General

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 August 2018, last major update June 2005

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed search: chondrosarcoma [title] bone

Cite this page: Pernick, N. Chondrosarcoma - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonechondrosarcoma.html. Accessed September 22nd, 2018.
Definition / general
  • Malignant cartilage forming tumor that does not produce osteoid
  • May arise from osteochondroma
  • Third most common bone malignancy after myeloma and osteosarcoma
  • Divided into conventional (central, peripheral, juxtacortical / periosteal) and variants (clear cell, dedifferentiation, mesenchymal, myxoid)
  • Higher levels of platelet derived growth factor isoform AA and PDGF-alpha receptor are present in chondrosarcomas vs. enchondromas / mature joint cartilage; higher levels also in high grade vs. low grade chondrosarcoma (Am J Surg Pathol 2001;25:1520)
Radiology images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

CT scan

Distal femur Xray

Femur Xray

Scapula Xray



AFIP images:

Central chondrosarcoma

Pubic symphysis

Scapula

Gross images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Grade 1 pubis

Proximal femur



AFIP images:

Rib

Lobular configuration

Intramedullary tumor

Knobby appearance

Juxtacortical chondrosarcoma

Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Grade 1

Grade 2


Hyaline type grade 1

Hyaline type grade 2

Hyaline type grade 3

Invading bone



AFIP images:

Well differentiated

Grade 1

Grade 1

Grade 1


Grade 2

Grade 2

Grade 3


Spindle cells

Reactive new bone

Edge infiltrates bone marrow

Penetrates cortex

Multinucleated stellate cell

Juxtacortical chondrosarcoma