Chronic multifocal osteomyelitis
Reviewers: Dariusz Borys, M.D. (see Reviewers page)
Revised: 7 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Recurrent variant of osteomyelitis in children and young adults of unknown origin (Hum Pathol 1999;30:59)
● Low grade fever, local swelling and pain
● Periods of exacerbation and remission over years
● Negative cultures
● Metaphyses of tubular bones, clavicle
● Multiple asymptomatic sites
● Associated skin lesion - pustulosis palmoplantaris
● Non steroidal anti-inflammatory drugs; do not use antibiotics since cultures are negative
● Early neutrophilic inflammation
● Late fibrosis of marrow with chronic inflammatory infiltrate
● Plasma cell predominance
● Fragments of necrotic bone with multinucleated giant cells
● Rheumatic disease
● Bacterial osteomyelitis
End of Bone > Osteomyelitis > Chronic multifocal osteomyelitis
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