Bone
Chondrogenic tumors - chondrosarcoma
Clear cell


Topic Completed: 1 March 2016

Revised: 29 October 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Chondrosarcoma clear cell

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Cite this page: Stockman DL. Clear cell. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneclearcellchondrosarcoma.html. Accessed November 12th, 2019.
Definition / general
  • Rare; usually third to fourth decades of life, more common in males
  • Epiphyses of long tubular bones
  • Have relatively low grade behavior, with 15% mortality at Mayo Clinic; may undergo dedifferentiation
Sites
  • Involves long bones, especially proximal femur and humerus
Clinical features
  • ~16% local recurrence rate
  • ~10% die from disease, may represent misdiagnosed conventional chondrosarcoma with clear cell chondrosarcoma component
  • Inadequate initial treatment results in high rate of local recurrence and metastasis
Radiology description
  • Typically arises in epiphysis or apophysis
  • Well defined, lytic, with punctate radiodensities corresponding to areas of mineralization
  • High signal intensity on T2 weighted images
Radiology images

AFIP images

Head of femur


Contributed by Dr. Mark R. Wick

Femoral neck

Treatment
  • Wide resection, often curative
Gross images

Contributed by Dr. Mark R. Wick

Femoral neck

Microscopic (histologic) description
  • Lobules of tumor cells with sharply defined borders, clear or ground-glass cytoplasm with vacuoles, central nuclei with occasional prominent nucleoli, numerous osteoclast-type giant cells, often mixed with small trabeculae of reactive bone
  • Any areas with conventional chondrosarcoma should be diagnosed as conventional chondrosarcoma with clear cell chondrosarcoma features and graded appropriately
  • May have secondary aneurysmal bone cyst changes
Microscopic (histologic) images

AFIP images

Delicate powdery to clear cytoplasm

Variably clear cytoplasm

Well differentiated



Contributed by Dr. Mark R. Wick

Various images

Positive stains
Electron microscopy description
  • Chondroid cells in various stages of differentiation
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