Other tumors of bone
Desmoplastic fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: desmoplastic fibroma [title] bone

Cite this page: Desmoplastic fibroma. website. Accessed October 26th, 2016.
Definition / General
  • Rare, benign / borderline behavior; bony counterpart of soft tissue fibromatosis
  • 75% younger than age 30 years, may be more common in males
  • Sites: metaphysis of long bones (56%), mandible (26%), pelvis (14%)
Radiology Description
  • Lytic and honeycombed (“soap bubble” appearance) metaphyseal lesions, cortical thinning with soft tissue extension
Case Reports
  • Wide local excision to prevent otherwise frequent recurrences
  • Causes local destruction, no metastases
Gross Description
  • White gray, fibrous rubbery mass with variable bony spicules and cysts
Micro Description
  • Mature, bland fibroblasts separated by abundant collagen with thin walled, dilated vascular channels
  • May infiltrate into soft tissue
  • No necrosis, no pleomorphism or atypia, no mitotic activity
Micro Images
Images hosted on other servers:

Bland spindle cells infiltrating into soft tissue

Molecular / Cytogenetics Description
  • Trisomy 8, trisomy 20
Electron Microscopy Description
  • Predominantly myofibroblasts, also fibroblasts and primitive mesenchymal cells
Additional References