Epithelioid osteosarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Epithelioid osteosarcoma
Cite this page: Epithelioid osteosarcoma. website. Accessed September 25th, 2018.
Definition / general
  • Rare pattern with rosette-like configuration simulating glands
  • Usually male patients under age 30
  • Sites: metaphysis of long tubular bones
  • Survival: poor, with 75% dead of multiple lung metastases despite surgery with wide margins and systemic chemotherapy; estimated 5 year survival of 15
Radiology description
  • Highly destructive with variable mineralization
Case reports
Microscopic (histologic) description
  • Osteoblastic osteosarcoma with small multinodular growth pattern, lacelike osteoid deposits, hemangiopericytoma-like vessels, rosette-like formation, epithelioid tumor cells
Microscopic (histologic) images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Cytology images

Images hosted on Pathout server:

FNAB - contributed by Dr. Mark R. Wick

Positive stains
Additional references