Bone & joints
Epithelioid osteosarcoma

Topic Completed: 1 August 2013

Revised: 28 December 2018

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Epithelioid osteosarcoma

Nat Pernick, M.D.
Page views in 2019: 637
Page views in 2020 to date: 591
Cite this page: Pernick N Epithelioid osteosarcoma. website. Accessed October 20th, 2020.
Definition / general
  • Rare pattern with rosette-like configuration simulating glands
  • Usually male patients under age 30
  • Sites: metaphysis of long tubular bones
  • Survival: poor, with 75% dead of multiple lung metastases despite surgery with wide margins and systemic chemotherapy; estimated 5 year survival of 15
Radiology description
  • Highly destructive with variable mineralization
Case reports
Microscopic (histologic) description
  • Osteoblastic osteosarcoma with small multinodular growth pattern, lacelike osteoid deposits, hemangiopericytoma-like vessels, rosette-like formation, epithelioid tumor cells
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick
Cytology images

Contributed by Dr. Mark R. Wick


Positive stains
Additional references
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