Bone
Fibrous and Fibroosseous tumors of bone
Polyostotic

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 October 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Polyostotic fibrous dysplasia

Related topics: Fibrous dysplasia, Monostotic, McCune-Albright syndrome, Mazabraud syndrome, Fibrous dysplasia protuberans

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Table of Contents
Definition / general
Cite this page: Polyostotic. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonefibrousdysplasiapolyostotic.html. Accessed June 15th, 2019.
Definition / general
  • 20% of cases, slightly younger than monostotic patients, may persist into adulthood
  • Involvement of shoulder and pelvic girdles causes crippling deformities, fractures
  • Sites: femur, skull, tibia; craniofacial involvement in 100% with extensive skeletal disease, 50% otherwise; usually unilateral
  • Associated with progressive disease (recurring fractures, long bone deformities, facial deformities), worse if earlier age of onset; rare malignant transformation into sarcoma, more likely after radiation
  • 50% have abnormal cutaneous pigmentation
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