Bone
Other tumors of bone
Giant cell granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 October 2016, last major update June 2005

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: giant cell granuloma [title] bone

Cite this page: Giant cell granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonegiantcellreparative.html. Accessed December 9th, 2016.
Definition / General
  • Formerly called giant cell reparative granuloma
  • Giant cell lesion primarily of jaw, also other craniofacial bones and short tubular bones of hands and feet
  • May be response to injury, but some cases behave aggressively
  • Giant cells have features of macrophages and osteoclasts; mononuclear cells appear to be proliferative, not giant cells
Radiology Images
Images hosted on PathOut server:

Cherubism - contributed by Dr. Mark R. Wick

Foot xray - contributed by Dr. Mark R. Wick

Jaw xray - contributed by Dr. Mark R. Wick

Peripheral type, distal tibia - contributed by Dr. Mark R. Wick

Metatarsal



Images hosted on other servers:

CT scan

Case Reports
Gross Description
  • Unencapsulated, brittle, brown purple, granulation tissue mass
Micro Description
  • Fibrillar connective tissue stroma with small oval and spindly mononuclear cells mixed with uneven clusters of multinuclear (5 - 40) giant cells
  • Small capillaries, hemorrhage, hemosiderin, reactive bone with osteoblastic rimming
  • No pleomorphism, no / rare mitotic figures
Micro Images
Images hosted on PathOut server:

Cherubism - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Background is fibrous stroma

Giant cells present in granuloma-like aggregates



Images hosted on other servers:

H&E, CD68, Ki67

Positive Stains