Bone
Other tumors of bone
Giant cell granuloma


Topic Completed: 1 June 2005

Revised: 11 July 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed search: giant cell granuloma [title] bone

Nat Pernick, M.D.
Page views in 2018: 5,835
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Cite this page: Pernick N. Giant cell granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bonegiantcellreparative.html. Accessed October 21st, 2019.
Definition / general
  • Formerly called giant cell reparative granuloma
  • Giant cell lesion primarily of jaw, also other craniofacial bones and short tubular bones of hands and feet
  • May be response to injury but some cases behave aggressively
  • Giant cells have features of macrophages and osteoclasts; mononuclear cells appear to be proliferative, not giant cells
Radiology images

AFIP images

Metatarsal


Contributed by Dr. Mark R. Wick

Cherubism

Foot Xray

Jaw Xray

Peripheral type, distal tibia



Images hosted on other servers:

CT scan

Case reports
Gross description
  • Unencapsulated, brittle, brown purple, granulation tissue mass
Microscopic (histologic) description
  • Fibrillar connective tissue stroma with small oval and spindly mononuclear cells mixed with uneven clusters of multinuclear (5 - 40) giant cells
  • Small capillaries, hemorrhage, hemosiderin, reactive bone with osteoblastic rimming
  • No pleomorphism, no / rare mitotic figures
Microscopic (histologic) images

AFIP images

Background is fibrous stroma

Giant cells present in granuloma-like aggregates


Contributed by Dr. Mark R. Wick

Cherubism



Images hosted on other servers:

H&E, CD68, Ki67

Positive stains
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