Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Bone

Non-neoplastic or metabolic disease

Glomus coccygeum


Reviewers: Dariusz Borys, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Glomus bodies normally are present near coccyx at caudal end of spinal column
● May be misidentified as a tumor during rectal resection for rectal or uterine carcinoma, treatment of pressure sores or trauma (Am J Surg Pathol 1990;14:922)
● Not a pathologic finding, but an unusual “normal” finding

Gross description
=========================================================================

● Small nodule in soft tissue ventral to tip of coccyx

Micro description
=========================================================================

● 1-4 cm, sharply circumscribed glomus bodies composed of glomus cells without atypia or pleomorphism surrounding vascular channels with fibrous stroma containing nerve fibers (Arch Pathol Lab Med 1999;123:905)
● Cells are small with moderate cytoplasm and finely dispersed chromatin
● No infiltration or expansile growth

Micro images
=========================================================================



H&E and stains

Positive stains
=========================================================================

● Vimentin, smooth muscle actin, neuron specific enolase

Negative stains
=========================================================================

● S100, desmin, CD31, Factor VIII related antigen

Electron macroscopy
=========================================================================

● Small cells with bundles of actin filaments

Electron macroscopy images
=========================================================================



Smooth muscle cells with actin filaments

Differential diagnosis
=========================================================================

Glomus tumor: branching vascular channels separated by stroma containing glomus cells in nests, aggregates; glomus cells are arranged around vessels; have small, regular, round, indistinct nucleoli; more infiltrative in children

End of Bone > Non-neoplastic or metabolic disease > Glomus coccygeum


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).