Vascular tumors of bone

Topic Completed: 1 June 2005

Revised: 2 January 2019, last major update June 2005

Copyright: (c) 2003-2019,, Inc.

PubMed search: hemangioendothelioma [title] bone

Nat Pernick, M.D.
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Page views in 2020 to date: 167
Cite this page: Pernick N Hemangioendothelioma . website. Accessed May 30th, 2020.
Definition / general
  • Some authors combine with angiosarcoma
  • See also epithelioid hemangioendothelioma
  • <100 cases reported
  • Borderline or intermediate grade malignancy
  • Wide age distribution
  • Often multiple, associated with similar skin and soft tissue lesions located nearby
  • Prolonged clinical course; only rarely metastases
  • Tend to develop in long tubular bones, but may occur in any bone; 50% are multifocal
Radiology description
  • Lytic, expansile, may erode cortex and infiltrate soft tissue
  • Variable margins
  • Curettage, en bloc resection and radiotherapy
  • Protracted clinical course with 20% dying of disease
Gross description
  • 2 - 10 cm, solid, tannish white
Microscopic (histologic) description
  • Sheets or cords of epithelioid or histiocyte-like epithelial cells with abundant eosinophilic cytoplasm, often vacuolated, with large vesicular nucleus, nuclear atypia less than angiosarcoma
  • Variable nuclear grooves, rare / no mitotic activity, well formed vessels but no / rare anastomosing channels, new / old hemorrhage, no lobular growth pattern
  • Stroma is hyalinized or basophilic, may appear chondroid, variable eosinophilic and lymphocytic infiltrate, may have osteoclast-like giant cells
Positive stains
Negative stains
Additional references
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