Vascular tumors of bone
Epithelioid hemangioma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 October 2016, last major update June 2005

Copyright: (c) 2003-2016,, Inc.

PubMed search: epithelioid hemangioma [title] bone

Related topics: Hemangioma
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Cite this page: Epithelioid hemangioma. website. Accessed August 21st, 2019.
Definition / general
  • Rare; usually affects long tubular and flat bones, but may occur in any bone
  • Also occurs in skin and subcutis
  • Mean age 34 - 46 years, range teens to 70’s
  • 25% multifocal
Radiology description
  • Lytic or blastic, well defined or poorly circumscribed margins
  • Curettage, excellent prognosis
Gross description
  • 2 - 15 cm
  • Well circumscribed, soft, dark red, limited to medullary cavity
Microscopic (histologic) description
  • Replaces marrow, surrounds bony trabeculae, erodes cortex, may have soft tissue component
  • Lobular growth pattern
  • Epithelioid cells line well formed vessels, but may also grow in sheets and cords; nuclei are grooved, vesicular, may have prominent nucleoli
  • No severe nuclear atypia
  • Abundant eosinophilic cytoplasm, often with vacuoles
  • < 5 mitotic figures / 10 HPF
  • Stroma is loose connective tissue with lymphocytes, eosinophils, extravasated red blood cells
Positive stains
Differential diagnosis
Additional references
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